The efficacy of botulinum toxin A lower limb injections in addition to physiotherapy approaches in children with cerebral palsy: A systematic review

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dc.authoridYANA, METEHAN/0000-0002-9290-1716
dc.contributor.authorYana, Metehan
dc.contributor.authorTutuola, Fadodun
dc.contributor.authorWestwater-Wood, Sarah
dc.contributor.authorKavlak, Erdogan
dc.date.accessioned2024-09-29T16:07:58Z
dc.date.available2024-09-29T16:07:58Z
dc.date.issued2019
dc.departmentKarabük Üniversitesien_US
dc.description.abstractBACKGROUND: To assess treatment effect of lower limb botulinum toxin type A (BTX-A) in combination with physiotherapy approaches on gross motor functions in children with cerebral palsy compared with only physiotherapy treatment. OBJECTIVE: The purpose of this review was to analyze the efficacy botulinum toxin a lower limb injections in addition to physiotherapy approaches in children with cerebral palsy. METHODS: A literature search was conducted in the following databases: Cochrane, PEDro, PubMed, MEDLINE, AMED and EMBASE. The searches were limited to the period from July 2009 to July 2015. The intervention had to contain BTX-A into the lower limb plus physiotherapy approaches and be compared with only physiotherapy. The methodological quality and clinical relevance were independently assessed by the authors. RESULTS: The database search resulted in a total of 1521 studies, of which 4 (Level II of evidence) trials were included in this review. The population represented by were age between from 11 month to 15 years. Overall there were 153 children all diagnosed with CP (87 Male, 66 Female). CONCLUSIONS: The use of BTX-A injections in addition to physiotherapy approaches seems to have positive effect on spasticity and ROM. However, the question of whether the treatment of BTX-A plus physiotherapy has a greater improvement on functional capacity, such as gross motor function or gait parameter than only physiotherapy treatments, was inconclusive. Further investigation by rigorous studies is required.en_US
dc.identifier.doi10.3233/NRE-182581
dc.identifier.endpage189en_US
dc.identifier.issn1053-8135
dc.identifier.issn1878-6448
dc.identifier.issue2en_US
dc.identifier.pmid30856126en_US
dc.identifier.scopus2-s2.0-85064821732en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage175en_US
dc.identifier.urihttps://doi.org/10.3233/NRE-182581
dc.identifier.urihttps://hdl.handle.net/20.500.14619/7289
dc.identifier.volume44en_US
dc.identifier.wosWOS:000465434400002en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherIos Pressen_US
dc.relation.ispartofNeurorehabilitationen_US
dc.relation.publicationcategoryDiğeren_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPhysiotherapyen_US
dc.subjectcerebral palsyen_US
dc.subjectbotulinum toxin type Aen_US
dc.subjectGMFCSen_US
dc.subjectGMFMen_US
dc.titleThe efficacy of botulinum toxin A lower limb injections in addition to physiotherapy approaches in children with cerebral palsy: A systematic reviewen_US
dc.typeReviewen_US

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