Co-doped hydroxyapatites as potential materials for biomedical applications

Basit Öğe Kaydı
dc.authoridAlshemary, Ammar Z/0000-0001-5367-1869
dc.authoridYilmaz Erdemli, Bengi/0000-0001-7642-4684
dc.authoridEvis, Zafer/0000-0002-7518-8162
dc.contributor.authorYilmaz, Bengi
dc.contributor.authorAlshemary, Ammar Z.
dc.contributor.authorEvis, Zafer
dc.date.accessioned2024-09-29T15:57:57Z
dc.date.available2024-09-29T15:57:57Z
dc.date.issued2019
dc.departmentKarabük Üniversitesien_US
dc.description.abstractHydroxyapatite (HA) is a synthetic biomaterial resembling the composition of mammalian hard tissue and thus, it is widely employed as a bone graft material, hard tissue engineering scaffold and coating layer for metallic substrates. Biological apatite is non-stoichiometric in nature. It is composed of small crystals and characterized by poor crystallinity and relatively high solubility with respect to stoichiometric HA. Chemical compositions of these crystals consist of Ca, P and trace amounts of various ions, such as Mg2+, Zn2+, Sr2+, Ag+, Cl- and F- which are more prominent as dopants or adsorbed on the crystal surface. However, these ions play an important role in the metabolism of hard tissues. Synthetic HA is a stoichiometric material with a Ca/P ratio of 1.67, which lacks the presence of valuable trace ions regularly present in natural hard tissue. Thus, the structure of synthetic HA is partially incorporated by these ions to mimic the chemical composition of the biological apatite structure. Ionic substitutions have been planned as a tool to enhance the biological role of HA based materials. As single dopant frameworks have indicated great outcomes, it makes sense that various dopants can be utilized to further build the valuable impacts of each, within the constraints of the material stability of HA. This review is focused on co-ionic substitutions in HA system and their combined effects on related biomedical characteristics.en_US
dc.identifier.doi10.1016/j.microc.2018.10.007
dc.identifier.endpage453en_US
dc.identifier.issn0026-265X
dc.identifier.issn1095-9149
dc.identifier.scopus2-s2.0-85054338747en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage443en_US
dc.identifier.urihttps://doi.org/10.1016/j.microc.2018.10.007
dc.identifier.urihttps://hdl.handle.net/20.500.14619/5114
dc.identifier.volume144en_US
dc.identifier.wosWOS:000449893000059en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevier Science Bven_US
dc.relation.ispartofMicrochemical Journalen_US
dc.relation.publicationcategoryDiğeren_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBiological apatiteen_US
dc.subjectHydroxyapatiteen_US
dc.subjectCo-dopingen_US
dc.subjectIonic substitutionsen_US
dc.subjectBiomedical propertiesen_US
dc.subjectCalcium phosphatesen_US
dc.titleCo-doped hydroxyapatites as potential materials for biomedical applicationsen_US
dc.typeReviewen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu