Salivary Del-1, IL-17, and LFA-1 levels in periodontal health and disease

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dc.authoridMEHMET AKIF, ESKAN/0000-0002-5440-0291
dc.authoridHakki, Sema/0000-0001-8665-6235
dc.contributor.authorInonu, Elif
dc.contributor.authorKayis, Seyit Ali
dc.contributor.authorEskan, Mehmet Akif
dc.contributor.authorHakki, Sema S.
dc.date.accessioned2024-09-29T16:04:41Z
dc.date.available2024-09-29T16:04:41Z
dc.date.issued2020
dc.departmentKarabük Üniversitesien_US
dc.description.abstractObjective and Background Developmental endothelial locus-1 (Del-1), lymphocyte function-associated antigen-1 (LFA-1), and interleukin 17 (IL-17) play critical roles in transendothelial migration of neutrophils in periodontal diseases. The aim of this study was to evaluate salivary Del-1, IL-17, and LFA-1 protein levels in patients with gingivitis (G), chronic periodontitis (CP), and generalized aggressive periodontitis (GAP). Methods A total of 180 systemically healthy, non-smoking patients (45 periodontally healthy (H) and 45 G, 50 CP, and 40 GAP) individuals (between March 2014 and February 2016) were included in this study according to Armitage's (1999) classification. Clinical periodontal parameters, including clinical attachment level, probing depth, plaque index, and gingival index, were recorded. Del-1, IL-17, and LFA-1 protein expression levels were measured in unstimulated saliva samples collected from patients by using enzyme-linked immunosorbent assays.Kruskal-WallisandMann-Whitney U testswere used for multiple comparisons and post hoc statistical analyses, respectively. ROC curve analysis was used to evaluate the sensitivity and specificity of Del-1, IL-17, and LFA-1 in distinguishing periodontal disease from health and gingivitis. Results It was found a high level of IL-17 and a low level of Del-1 in the CP and GAP, as compared to the G and H groups (P < .001). Nevertheless, we found LFA-1 levels were higher in the GAP than in the CP or G groups (P = .00). Consistently, LFA-1 levels were lower in the H and G groups than in the CP and GAP groups (P = .00). The combination of three biomarkers was found as the best predictor yielded exhibited the highest AUC [0.893, 0.845-0.94 (%95 CI)P < .001] in discriminating periodontal disease from health and gingivitis. Conclusion Salivary Del-1, LFA-1, and IL-17 levels might be useful markers for determining the clinical health and disease status of patients with periodontitis. However, further studies that evaluate the level of salivary Del-1, LFA-1, and IL-17 before and after periodontal therapy are required to understand the exact roles of these cytokines during the periodontal healing period.en_US
dc.description.sponsorshipScientific Research Projects of Selcuk University [SELCUK/BAP-14102025] Funding Source: Medlineen_US
dc.identifier.doi10.1111/jre.12738
dc.identifier.endpage518en_US
dc.identifier.issn0022-3484
dc.identifier.issn1600-0765
dc.identifier.issue4en_US
dc.identifier.pmid32153040en_US
dc.identifier.scopus2-s2.0-85081240067en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage511en_US
dc.identifier.urihttps://doi.org/10.1111/jre.12738
dc.identifier.urihttps://hdl.handle.net/20.500.14619/6264
dc.identifier.volume55en_US
dc.identifier.wosWOS:000554062800005en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Periodontal Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectcytokinesen_US
dc.subjectinterleukin-17en_US
dc.subjectlymphocyte function-associated antigen-1en_US
dc.subjectperiodontitisen_US
dc.subjectsalivaen_US
dc.titleSalivary Del-1, IL-17, and LFA-1 levels in periodontal health and diseaseen_US
dc.typeArticleen_US

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