The prognostic and predictive significance of serum thiols and disulfide levels in advanced non-small cell lung cancer

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dc.authoridHaskul, Ismail/0000-0001-5125-1035
dc.authoridAl lahham, Salim/0000-0001-7571-5949
dc.authoridneselioglu, salim/0000-0002-0974-5717
dc.authoridAcat, Murat/0000-0002-7163-4882
dc.authoridSahin, Suleyman/0000-0001-9769-2565
dc.contributor.authorKaratas, Fatih
dc.contributor.authorAcat, Murat
dc.contributor.authorSahin, Suleyman
dc.contributor.authorInci, Fatih
dc.contributor.authorKaratas, Gulsah
dc.contributor.authorNeselioglu, Salim
dc.contributor.authorHaskul, Ismail
dc.date.accessioned2024-09-29T16:02:52Z
dc.date.available2024-09-29T16:02:52Z
dc.date.issued2020
dc.departmentKarabük Üniversitesien_US
dc.description.abstractSerum Total Thiol (TT), Native Thiol (NT), and Disulfide (SS) levels were found significantly lower in benign proliferative pathologies and cancer disease compared to healthy subjects. We conducted this prospective study to investigate the possible predictive and prognostic significance of these markers in non-small cell lung cancer (NSCLC), which is one of the most associated cancers with oxidative stress. This was a non-randomized, prospective, and case-control study of 120 subjects, including 60 patients with metastatic or inoperable NSCLC at the time of diagnosis and 60 demographically-matched controls. Morning fasting venous blood serum samples from both NSCLC and control group were stored at -80 degrees C for equal periods and then TT, NT, and SS levels were measured spectrophotometrically. Serum TT, NT, and SS levels were compared between groups and their relationships with demographic features and survival of NSCLC patients were analyzed. In results, Serum TT, NT, and SS levels were significantly lower in NSCLC patients than those in control group, with a low SS level being an independent indicator of poor survival.en_US
dc.identifier.doi10.1080/13685538.2018.1559805
dc.identifier.endpage628en_US
dc.identifier.issn1368-5538
dc.identifier.issn1473-0790
dc.identifier.issue5en_US
dc.identifier.pmid30651017en_US
dc.identifier.scopus2-s2.0-85060178431en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage619en_US
dc.identifier.urihttps://doi.org/10.1080/13685538.2018.1559805
dc.identifier.urihttps://hdl.handle.net/20.500.14619/5764
dc.identifier.volume23en_US
dc.identifier.wosWOS:000641856000042en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofAging Maleen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectThiolsen_US
dc.subjectdisulfideen_US
dc.subjectlevelsen_US
dc.subjectnon-small cell lung canceren_US
dc.subjectsurvivalen_US
dc.subjectbiomarkeren_US
dc.titleThe prognostic and predictive significance of serum thiols and disulfide levels in advanced non-small cell lung canceren_US
dc.typeArticleen_US

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