Biochemical investigation of the toxic effects of acrylamide administration during pregnancy on the liver of mother and fetus and the protective role of vitamin E

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dc.authoridGozukara Bag, Harika Gozde/0000-0003-1208-4072
dc.authoridAltinoz, Eyup/0000-0002-3991-9773
dc.contributor.authorErdemli, Mehmet Erman
dc.contributor.authorAltinoz, Eyup
dc.contributor.authorAksungur, Zeynep
dc.contributor.authorTurkoz, Yusuf
dc.contributor.authorDogan, Zumrut
dc.contributor.authorBag, Harika Gozukara
dc.date.accessioned2024-09-29T16:02:53Z
dc.date.available2024-09-29T16:02:53Z
dc.date.issued2017
dc.departmentKarabük Üniversitesien_US
dc.description.abstractObjectives: To investigate the toxic effects occurring in the liver tissues of the pregnant rats and the fetuses, which are administered acrylamide and vitamin E as a protector during pregnancy. Materials and methods: This research was conducted with the permission of Laboratory Animals Ethical Board of Inonu University Faculty of Medicine. Forty rats, of which their pregnancy is validated via vaginal smear, were distributed into five different groups. On the 20th day of pregnancy, pregnant rats and fetuses are decapitated. Malondialdehyde (MDA), reduced glutathione (GSH), total antioxidant status (TAS), total oxidant status (TOS) and xanthine oxidase (XO) levels were measured in the liver samples taken from mother and fetuses. Results: It was detected that acrylamide administered during pregnancy increased MDA, TOS, XO levels statistically significantly and decreased the GSH level (p <= 0.05) in the pregnant rat liver tissue when compared to all other groups. In the vitamin E administered group; GSH, TAS levels significantly increased statistically and TOS and XO levels dropped to levels of the control group (p <= 0.05), in comparison to all other groups. Among all groups, no biochemical changes were observed in the fetus liver tissue (p > 0.05). Conclusion: The liver of pregnant rats functions as a protective pre-filter by detoxifying acrylamide effectively and the acrylamide that reaches fetus liver is detoxified by the cytochrome P-450 system of the fetus liver. To be able to figure out the biochemical mechanism, more advanced studies are needed.en_US
dc.identifier.doi10.1080/14767058.2016.1188381
dc.identifier.endpage848en_US
dc.identifier.issn1476-7058
dc.identifier.issn1476-4954
dc.identifier.issue7en_US
dc.identifier.pmid27161006en_US
dc.identifier.scopus2-s2.0-84969781271en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage844en_US
dc.identifier.urihttps://doi.org/10.1080/14767058.2016.1188381
dc.identifier.urihttps://hdl.handle.net/20.500.14619/5771
dc.identifier.volume30en_US
dc.identifier.wosWOS:000399742300015en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofJournal of Maternal-Fetal & Neonatal Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcrylamideen_US
dc.subjectliveren_US
dc.subjectoxidative stressen_US
dc.subjectpregnant raten_US
dc.subjectvitamin Een_US
dc.titleBiochemical investigation of the toxic effects of acrylamide administration during pregnancy on the liver of mother and fetus and the protective role of vitamin Een_US
dc.typeArticleen_US

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