Assessment of the cytotoxicity and biocompatibility of chitosan nanostructures

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dc.contributor.authorÖzdemir, O.
dc.contributor.authorKopac, T.
dc.date.accessioned2024-09-29T16:21:11Z
dc.date.available2024-09-29T16:21:11Z
dc.date.issued2024
dc.departmentKarabük Üniversitesien_US
dc.description.abstractChitosan has found wide applications in biomedical, pharmaceutical, and dental areas. However, its limited water solubility and compact crystal structure significantly limit its clinical utilization, while the properties can be enhanced upon modification of its structure. Novel chitosan nanostructures have aroused attention in biomedical applications owing to their tunable physical and chemical structures, cost-effectiveness, enhanced solubility, biocompatibility, biodegradability, nontoxicity, mechanical and antibacterial properties. For the emergence of novel structures for biomedical implementation, their characterization in terms of in vitro and in vivo cytotoxicity and biocompatibility has to be assessed. This chapter presents a review of the biocompatibility and cytotoxicity evaluation of a number of chitosan-based nanoparticles (NPs) for biomedical relevance. The studies provide evidence of considerable indications of chitosan NPs in drug-based therapies on the basis of their biocompatibility, biodegradability, lower cytotoxicity, and higher stability offering novel perspectives for extending their utilization in biological areas. © 2024 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/B978-0-443-21891-0.00020-2
dc.identifier.endpage394en_US
dc.identifier.isbn978-044321891-0
dc.identifier.isbn978-044321892-7
dc.identifier.scopus2-s2.0-85193355373en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage375en_US
dc.identifier.urihttps://doi.org/10.1016/B978-0-443-21891-0.00020-2
dc.identifier.urihttps://hdl.handle.net/20.500.14619/9596
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofChitosan-Based Hybrid Nanomaterialsen_US
dc.relation.publicationcategoryKitap Bölümü - Uluslararasıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectantibacterialen_US
dc.subjectbiocompatibilityen_US
dc.subjectchitosan nanocompositesen_US
dc.subjectChitosan nanoparticlesen_US
dc.subjectcytotoxicityen_US
dc.subjectdrug deliveryen_US
dc.titleAssessment of the cytotoxicity and biocompatibility of chitosan nanostructuresen_US
dc.typeBook Parten_US

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