Ameliorative effects of crocin on tartrazine dye-induced pancreatic adverse effects: a biochemical and histological study

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dc.authoridAltinoz, Eyup/0000-0002-3991-9773
dc.authoridGozukara Bag, Harika Gozde/0000-0003-1208-4072
dc.contributor.authorErdemli, Zeynep
dc.contributor.authorAltinoz, Eyup
dc.contributor.authorErdemli, Mehmet Erman
dc.contributor.authorGul, Mehmet
dc.contributor.authorGozukara, Harika
dc.contributor.authorGul, Semir
dc.date.accessioned2024-09-29T15:51:26Z
dc.date.available2024-09-29T15:51:26Z
dc.date.issued2021
dc.departmentKarabük Üniversitesien_US
dc.description.abstractThe present study aimed to analyze the impact of tartrazine (T) and crocin (Cr) applications on the pancreas tissues of the Wistar rats. A total of 40 Wistar rats were randomly divided into 4 groups with 10 rats in each group, including the Control, T, Cr, and T + Cr groups. After 3 weeks of application, the pancreatic tissues of the rats were removed under anesthesia and rat blood samples were obtained. Tissues were analyzed with biochemical and histopathological methods. It was determined that T administration increased malondialdehyde (MDA), total oxidant status (TOS), oxidative stress index (OSI), glucose, triglyceride, LDL, VLDL, and total cholesterol levels. However, it decreased reduced glutathione (GSH), total antioxidant status (TAS), superoxide dismutase (SOD), catalase (CAT), and HDL levels when compared with the other groups. It was observed that Cr administration significantly increased GSH, SOD, CAT, TAS, and HDL levels when compared with the control group. In the T group, histopathological changes were observed in pancreatic tissue, leading to damages in exocrine pancreas and islets of Langerhans and increased caspase-3 immunoreactivity (p <= 0.001). Co-administration of Cr and T brought the biochemical and histopathological findings closer to the control group levels. The administration of T induced damage in the pancreas with the administered dose and frequency. Cr can increase the antioxidant capacity in pancreas tissue. Co-administration of T and Cr contributed to the reduction of the toxic effects induced by T. It could be suggested that Cr administration ameliorated T toxicity.en_US
dc.identifier.doi10.1007/s11356-020-10578-6
dc.identifier.endpage2218en_US
dc.identifier.issn0944-1344
dc.identifier.issn1614-7499
dc.identifier.issue2en_US
dc.identifier.pmid32870427en_US
dc.identifier.scopus2-s2.0-85090211443en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage2209en_US
dc.identifier.urihttps://doi.org/10.1007/s11356-020-10578-6
dc.identifier.urihttps://hdl.handle.net/20.500.14619/4075
dc.identifier.volume28en_US
dc.identifier.wosWOS:000565202500009en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofEnvironmental Science and Pollution Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectTartrazineen_US
dc.subjectPancreasen_US
dc.subjectCrocinen_US
dc.subjectOxidative stressen_US
dc.subjectRaten_US
dc.titleAmeliorative effects of crocin on tartrazine dye-induced pancreatic adverse effects: a biochemical and histological studyen_US
dc.typeArticleen_US

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