Crocin attenuates oxidative and inflammatory stress-related periodontitis in cardiac tissues in rats

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dc.authoridAYDIN, Tugba/0000-0002-9675-5509
dc.authoridGozukara Bag, Harika Gozde/0000-0003-1208-4072
dc.authoridZAYMAN, EMRAH/0000-0002-6578-3371
dc.authoridAltinoz, Eyup/0000-0002-3991-9773
dc.authorid/0000-0002-8920-2391
dc.contributor.authorKocaman, Gulhan
dc.contributor.authorAltinoz, Eyup
dc.contributor.authorErdemli, Mehmet Erman
dc.contributor.authorGul, Mehmet
dc.contributor.authorErdemli, Zeynep
dc.contributor.authorZayman, Emrah
dc.contributor.authorBag, Harika Gozde Gozukara
dc.date.accessioned2024-09-29T16:06:28Z
dc.date.available2024-09-29T16:06:28Z
dc.date.issued2021
dc.departmentKarabük Üniversitesien_US
dc.description.abstractBackground. Periodontitis, a chronic inflammatory disease affecting the supporting tissues around the teeth, causes significant inflammatory and oxidative changes in cardiac tissue. Crocin is the active constituent of Crocus sativus (saffron) which has antioxidant properties and is protective against cardiovascular disturbances. Objectives. The present study aimed to investigate the protective effects of crocin on periodontitis-induced oxidative/inflammatory cardiac degeneration in rats in vivo. Materials and methods. Thirty female Sprague Dawley rats were randomly divided into 3 groups: control group, periodontitis group (PD) and periodonditis plus crocin group (PD+Cr). Experimental periodontitis was induced by placing silk ligatures on the maxillary second molar teeth for 30 days. Afterward, crocin (100 mg/kg body weight/day) was administered to the PD+Cr group and saline was administered to the PD group and the control group for 15 days. The subjects were sacrificed on the 45th day. Results. Histological and biochemical analyses demonstrated that inducing periodontitis caused obvious damage to cardiac tissues which was significantly ameliorated by crocin (p < 0.05). Significant improvements in bone resorption parameters (cross-linked C-telopeptide of type I collagen and bone alkaline phosphatase) were also observed in the PD+Cr group (p < 0.05). In addition, crocin caused significant reductions of malondialdehyde levels and total oxidant score while antioxidant levels (glutathione, superoxide dismutase, total antioxidant score, and catalase) were significantly higher in PD+Cr group (p < 0.05). Conclusions. This study reveals that periodontitis may cause oxidative damage in cardiac tissue and crocin improves periodontitis-induced degenerative changes in heart tissue, which is associated with its antioxidant properties.en_US
dc.description.sponsorshipKarabuk University, Turkey [KBU-BAP-17-KP-360]en_US
dc.description.sponsorshipThis work was supported by a research fund from Karabuk University, Turkey (grant No. KBU-BAP-17-KP-360).en_US
dc.identifier.doi10.17219/acem/133753
dc.identifier.endpage524en_US
dc.identifier.issn1899-5276
dc.identifier.issn2451-2680
dc.identifier.issue5en_US
dc.identifier.pmid33974754en_US
dc.identifier.scopus2-s2.0-85106574459en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage517en_US
dc.identifier.urihttps://doi.org/10.17219/acem/133753
dc.identifier.urihttps://hdl.handle.net/20.500.14619/6842
dc.identifier.volume30en_US
dc.identifier.wosWOS:000657484700005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWroclaw Medical Univen_US
dc.relation.ispartofAdvances in Clinical and Experimental Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectperiodontitisen_US
dc.subjectinflammationen_US
dc.subjectantioxidantsen_US
dc.subjectcrocinen_US
dc.subjecthearten_US
dc.titleCrocin attenuates oxidative and inflammatory stress-related periodontitis in cardiac tissues in ratsen_US
dc.typeArticleen_US

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