Protective effect of crocin on food azo dye tartrazine-induced hepatic damage by improving biochemical parameters and oxidative stress biomarkers in rats

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dc.authoridAltinoz, Eyup/0000-0002-3991-9773
dc.authoridGozukara Bag, Harika Gozde/0000-0003-1208-4072
dc.contributor.authorVelioglu, Cigdem
dc.contributor.authorErdemli, Mehmet E.
dc.contributor.authorGul, Mehmet
dc.contributor.authorErdemli, Zeynep
dc.contributor.authorZayman, Emrah
dc.contributor.authorBag, Harika G.
dc.contributor.authorAltinoz, Eyup
dc.date.accessioned2024-09-29T16:08:29Z
dc.date.available2024-09-29T16:08:29Z
dc.date.issued2019
dc.departmentKarabük Üniversitesien_US
dc.description.abstractThe objective of the present study was to demonstrate the protective effect of crocin on the adverse effects of tartrazine on liver. Crocin is a carotenoid and a strong free radical scavenger. Forty rats were randomly divided into 4 groups (n = 10). The first group was the control group (C) and saline solution was administered to this group. The second group (Cr) was administered 50 mg/ kg crocin. The third group (T) was administered 500 mg/kg tartrazine. The fourth group (T+Cr) was administered the same doses of both crocin and tartrazine as the previous groups for 21 days. It was determined that tartrazine increased liver superoxide dismutase (SOD) activity, malondialdehyde (MDA) and total oxidant status (TOS) levels and catalase (CAT) activity, decreased glutathione (GSH), and total antioxidant status (TAS) levels. Furthermore, tartrazine administration resulted in significant increases in plasma aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) activities and pathological changes in the liver. When tartrazine administered rats were treated with crocin for 21 days, the biochemical parameters improved, and liver tissues were restored. Thus, it was demonstrated that crocin had protective effects on the adverse effects caused by tartrazine administration.en_US
dc.description.sponsorshipKarabuk University scientific research fund [KBU-BAP-16/2-YL-093]en_US
dc.description.sponsorshipThe present study was sponsored by Karabuk University scientific research fund (KBU-BAP-16/2-YL-093).en_US
dc.identifier.doi10.4149/gpb_2018039
dc.identifier.endpage82en_US
dc.identifier.issn0231-5882
dc.identifier.issn1338-4325
dc.identifier.issue1en_US
dc.identifier.pmid30657462en_US
dc.identifier.scopus2-s2.0-85061474703en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage73en_US
dc.identifier.urihttps://doi.org/10.4149/gpb_2018039
dc.identifier.urihttps://hdl.handle.net/20.500.14619/7579
dc.identifier.volume38en_US
dc.identifier.wosWOS:000458604800007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAepress Sroen_US
dc.relation.ispartofGeneral Physiology and Biophysicsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectTartrazineen_US
dc.subjectCrocinen_US
dc.subjectOxidative stressen_US
dc.subjectHepatotoxicityen_US
dc.titleProtective effect of crocin on food azo dye tartrazine-induced hepatic damage by improving biochemical parameters and oxidative stress biomarkers in ratsen_US
dc.typeArticleen_US

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