The influence of RS738409 I148M polymorphism of patatin-like phospholipase domain containing 3 gene on the susceptibility of non-alcoholic fatty liver disease

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dc.authoridKutlu, Ozlem/0000-0002-3769-2536
dc.contributor.authorAkkiz, Hikmet
dc.contributor.authorTaskin, Emre
dc.contributor.authorKaraogullarindan, Umit
dc.contributor.authorDelik, Anil
dc.contributor.authorKuran, Sedef
dc.contributor.authorKutlu, Ozlem
dc.date.accessioned2024-09-29T16:03:12Z
dc.date.available2024-09-29T16:03:12Z
dc.date.issued2021
dc.departmentKarabük Üniversitesien_US
dc.description.abstractWe aimed to elucidate the frequency of polymorphic genotypes and alleles of patatin-like phospholipase domain containing 3 rs738409 polymorphism and its possible associations with non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis in a cohort from Turkey. We enrolled 200 patients diagnosed with NAFLD and genotyped for rs738409 I148M polymorphism by real-time polymerase chain reaction, particularly by melting curve analysis. SPSS analysis software was used for statistical significance. Continuous variable values were expressed as mean +/- standard deviation. Significant statistical level was chosen as p = 0.05. Our results demonstrate in a cohort from Turkey that rs738409 C > G polymorphism (I148M) of patatin-like phospholipase domain containing 3 gene is significantly able to affect individuals to have NAFLD in unadjusted regression model. Consistent with the previous studies in other populations, our study group showed a significantly higher risk of having NAFLD in unadjusted regression model but not in the adjusted model indicating that non-genetic factors such as age and sex may be responsible for the association. However, independent studies need to validate our findings with a larger group of NAFLD patients, as well as in different ethnic cohorts.en_US
dc.identifier.doi10.1097/MD.0000000000025893
dc.identifier.issn0025-7974
dc.identifier.issn1536-5964
dc.identifier.issue19en_US
dc.identifier.pmid34106646en_US
dc.identifier.scopus2-s2.0-85107960442en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttps://doi.org/10.1097/MD.0000000000025893
dc.identifier.urihttps://hdl.handle.net/20.500.14619/5942
dc.identifier.volume100en_US
dc.identifier.wosWOS:000658910800066en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofMedicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectNAFLDen_US
dc.subjectNASHen_US
dc.subjectPNPLA3en_US
dc.subjectrs738409en_US
dc.subjectTurkish patientsen_US
dc.titleThe influence of RS738409 I148M polymorphism of patatin-like phospholipase domain containing 3 gene on the susceptibility of non-alcoholic fatty liver diseaseen_US
dc.typeArticleen_US

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