Cannabis use in college: Genetic predispositions, peers, and activity participation

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dc.authoridMoore, Ashlee/0000-0002-6577-3050
dc.authoridWebb, Bradley/0000-0002-0576-5366
dc.authoridKsinan, Albert/0000-0003-3900-5098
dc.contributor.authorThomas, Nathaniel S.
dc.contributor.authorSalvatore, Jessica E.
dc.contributor.authorGillespie, Nathan A.
dc.contributor.authorAliev, Fazil
dc.contributor.authorKsinan, Albert J.
dc.contributor.authorDick, Danielle M.
dc.date.accessioned2024-09-29T15:55:16Z
dc.date.available2024-09-29T15:55:16Z
dc.date.issued2021
dc.departmentKarabük Üniversitesien_US
dc.description.abstractBackground: Among adult college students in the US, cannabis use is common and associated with considerable negative consequences to health, cognition, and academic functioning, underscoring the importance of identifying risk and protective factors. Cannabis use is influenced by genetic factors, but genetic risk is not determinative. Accordingly, it is critical to identify environments that reduce risk among those who are at elevated genetic risk. This study examined the impact of polygenic scores for cannabis initiation, various forms of social activity participation, and peer deviance on recent cannabis use. Our aim was to test whether these environments moderate genetic risk for cannabis use. Methods: Data came from a longitudinal sample of undergraduate college students of European American (EA; N-EA = 750) and African American (AA; N-AA = 405) ancestry. Generalized estimating equations with a logit link function were used to examine main effects and two-way interactions. Results: Engagement with church activities was associated with lower probability of cannabis use. Peer deviance was associated with higher probability of cannabis use. Engagement with community activities moderated the influence of the polygenic risk score in the EA sample, such that PRS was associated with recent cannabis use among those who never engaged in community activities. This effect did not replicate in AAs, which may have been due to the portability of PRS based on EA discovery samples. Conclusions: Results suggest that community activities may limit the influence of genetic risk, as associations between PRS and cannabis use were only observed among individuals who never engaged in community activities.en_US
dc.description.sponsorshipVirginia Commonwealth University; National Center for Research Resources [UL1RR031990]; National Institutes of Health Roadmap for Medical Research; National Institute on Drug Abuse of the National Institutes of Health [U54DA036105]; Center for Tobacco Products of the U.S. Food and Drug Administration; National Institute on Alcohol Abuse and Alcoholism [P20 AA017828, R37AA011408, K02AA018755, P50 AA022537, K01AA024152]en_US
dc.description.sponsorshipSpit for Science has been supported by Virginia Commonwealth University, P20 AA017828, R37AA011408, K02AA018755, P50 AA022537, and K01AA024152 from the National Institute on Alcohol Abuse and Alcoholism, and UL1RR031990 from the National Center for Research Resources and National Institutes of Health Roadmap for Medical Research. This research was also supported by the National Institute on Drug Abuse of the National Institutes of Health under Award Number U54DA036105 and the Center for Tobacco Products of the U.S. Food and Drug Administration. The content is solely the responsibility of the authors and does not necessarily represent the views of the NIH or the FDA. Data from this study are available to qualified researchers via dbGaP (phs001754.v2.p1). We would like to thank the Spit for Science participants for making this study a success, as well as the many University faculty, students, and staff who contributed to the design and implementation of the project.en_US
dc.identifier.doi10.1016/j.drugalcdep.2020.108489
dc.identifier.issn0376-8716
dc.identifier.issn1879-0046
dc.identifier.pmid33373877en_US
dc.identifier.scopus2-s2.0-85098215520en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1016/j.drugalcdep.2020.108489
dc.identifier.urihttps://hdl.handle.net/20.500.14619/4557
dc.identifier.volume219en_US
dc.identifier.wosWOS:000616136500005en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Ireland Ltden_US
dc.relation.ispartofDrug and Alcohol Dependenceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCannabisen_US
dc.subjectCollege studenten_US
dc.subjectPolygenic risk scoreen_US
dc.subjectGene-by-environment interactionen_US
dc.titleCannabis use in college: Genetic predispositions, peers, and activity participationen_US
dc.typeArticleen_US

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