Investigation of total cerebellar and flocculonodular lobe volume in Parkinson's disease and healthy individuals: a brain segmentation study

Basit Öğe Kaydı
dc.authoridSahin, Necati Emre/0000-0002-2061-7951
dc.authoridSahin, Bunyamin/0000-0001-8538-8443
dc.authoridOZGEN, Merve Nur/0000-0002-1134-5309
dc.contributor.authorOzgen, Merve Nur
dc.contributor.authorSahin, Necati Emre
dc.contributor.authorErtan, Nurcan
dc.contributor.authorSahin, Bunyamin
dc.date.accessioned2024-09-29T15:51:07Z
dc.date.available2024-09-29T15:51:07Z
dc.date.issued2024
dc.departmentKarabük Üniversitesien_US
dc.description.abstractBackground Parkinson's disease (PD) is a neurodegenerative disorder with an unexplored link to the cerebellum. In the pathophysiology of balance disorders in PD, the role of the flocculonodular lobe (FL) is linked to the impairment of the dopaminergic system. Dopamine deficiency can also lead to changes in cerebellum functions, disrupting balance control. This study compares cerebellar and FL volumes between healthy controls (HC) and PD patients, analyzing their correlation with clinical outcomes. Methods We used magnetic resonance images of 23 PD patients (14 male, 9 female) and 24 HC (9 male, 15 female). Intracranial (ICV), total cerebellar, FL, and cerebellar gray matter volumes were measured using VolBrain. Clinical outcomes in PD patients were assessed using the Unified Parkinson's Disease Rating Scale (UPDRS-III) to evaluate motor function, with scores correlated to volumetric data. Results The cerebellar and gray matter volumes in HC were 115.53 +/- 10.44 cm(3) and 84.83 +/- 7.76 cm(3), respectively, compared to 126.83 +/- 13.47 cm(3) and 92.37 +/- 9.45 cm(3) in PD patients, indicating significantly larger volumes in PD patients (p < 0.05). The flocculonodular lobe gray matter volume was 1.14 +/- 0.19 cm(3) in PD patients and 1.02 +/- 0.13 cm(3) in HC, but there was a significant increase in gray matter volume in PD patients between the groups (p < 0.05). In PD patients, significant negative correlations were observed between FL volume and the UPDRS-III scores (r = - 0.467, p = 0.033) and between UPDRS-III scores and both total (r = - 0.453, p = 0.039) and normalized (r = - 0.468, p = 0.032) gray matter volumes of the FL. Conclusion Although total gray matter volumes were larger in PD patients, the volumes of FL did not differ between groups. In Parkinson's disease, increased cerebellar volume may regulate fine motor movements rather than balance.en_US
dc.description.sponsorshipOndokuz Mayimath;s Universityen_US
dc.description.sponsorshipNo Statement Availableen_US
dc.identifier.doi10.1007/s10072-024-07509-5
dc.identifier.endpage4298en_US
dc.identifier.issn1590-1874
dc.identifier.issn1590-3478
dc.identifier.issue9en_US
dc.identifier.pmid38622454en_US
dc.identifier.scopus2-s2.0-85190388796en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage4291en_US
dc.identifier.urihttps://doi.org/10.1007/s10072-024-07509-5
dc.identifier.urihttps://hdl.handle.net/20.500.14619/3906
dc.identifier.volume45en_US
dc.identifier.wosWOS:001204741100002en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer-Verlag Italia Srlen_US
dc.relation.ispartofNeurological Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCerebellumen_US
dc.subjectVolumeen_US
dc.subjectMagnetic resonanceen_US
dc.subjectParkinson's diseaseen_US
dc.subjectVolBrainen_US
dc.titleInvestigation of total cerebellar and flocculonodular lobe volume in Parkinson's disease and healthy individuals: a brain segmentation studyen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu