Comparison of the effects of magnesium and ketamine on postoperative pain and morphine consumption. A double-blind randomized controlled clinical study

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dc.authoridHORASANLI, EYUP/0000-0002-6077-8549
dc.authoridArikan, Muge/0000-0003-2931-1729
dc.authoridASLAN, Bilge/0000-0001-6366-7548
dc.contributor.authorArikan, Muge
dc.contributor.authorAslan, Bilge
dc.contributor.authorArikan, Osman
dc.contributor.authorHorasanli, Eyup
dc.contributor.authorBut, Abdulkadir
dc.date.accessioned2024-09-29T16:06:24Z
dc.date.available2024-09-29T16:06:24Z
dc.date.issued2016
dc.departmentKarabük Üniversitesien_US
dc.description.abstractPURPOSE: To compare the effects of magnesium sulfate and ketamine on postoperative pain and total morphine consumption in a placebo-controlled design. METHODS: One hundred and twenty women scheduled for total abdominal hysterectomy were included in this prospective, randomized, double-blind study. Postoperatively, when the Numeric Pain Rating Scale (NPRS) was four or more, IV-PCA morphine was applied to all patients. The patients were randomized into three groups: Group K ketamine, Group M magnesium, and Group C saline received as infusion. Total morphine consumption for 48h, pain scores, adverse effects, and patients' satisfaction were evaluated. RESULTS: Total morphine consumption was significantly lower in Group K (32.6 +/- 9.2 mg) than in Group M (58.9 +/- 6.5 mg) and in Group C (65.7 +/- 8.2 mg). The satisfaction level of patients in Group K was higher than the other two groups (p<0.05). Pruritus and nausea were observed more frequently in Group C. CONCLUSION: The addition of ketamine to IV-PCA morphine reduces the total consumption of morphine without psychotic effects; however, magnesium did not influence morphine consumption.en_US
dc.identifier.doi10.1590/S0102-865020160010000010
dc.identifier.endpage73en_US
dc.identifier.issn0102-8650
dc.identifier.issn1678-2674
dc.identifier.issue1en_US
dc.identifier.pmid26840358en_US
dc.identifier.scopus2-s2.0-84956910097en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage67en_US
dc.identifier.urihttps://doi.org/10.1590/S0102-865020160010000010
dc.identifier.urihttps://hdl.handle.net/20.500.14619/6815
dc.identifier.volume31en_US
dc.identifier.wosWOS:000369657900010en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherActa Cirurgica Brasileiraen_US
dc.relation.ispartofActa Cirurgica Brasileiraen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAnalgesia, Patient-Controlleden_US
dc.subjectMorphineen_US
dc.subjectMagnesium Sulfateen_US
dc.subjectKetamineen_US
dc.titleComparison of the effects of magnesium and ketamine on postoperative pain and morphine consumption. A double-blind randomized controlled clinical studyen_US
dc.typeArticleen_US

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