Investigation of the protective effects of crocin on acrylamide induced small and large intestine damage in rats

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dc.authoridGozukara Bag, Harika Gozde/0000-0003-1208-4072
dc.authoridYigitcan, Birgul/0000-0002-7910-4595
dc.authoridAltinoz, Eyup/0000-0002-3991-9773
dc.contributor.authorGedik, S.
dc.contributor.authorErdemli, M. E.
dc.contributor.authorGul, M.
dc.contributor.authorYigitcan, B.
dc.contributor.authorBag, H. Gozukara
dc.contributor.authorAksungur, Z.
dc.contributor.authorAltinoz, E.
dc.date.accessioned2024-09-29T16:02:50Z
dc.date.available2024-09-29T16:02:50Z
dc.date.issued2018
dc.departmentKarabük Üniversitesien_US
dc.description.abstractWe investigated repair of acrylamide (AA) induced damage in intestines by administration of crocin. We used 40 male Wistar rats in four groups of 10 animals: control, AA, crocin, and AA + crocin groups. We investigated biochemical and histological changes to small and large intestine. AA ingestion decreased glutathione (GSH) levels and total antioxidant status (TAS) in the intestine compared to the control group, while superoxide dismutase (SOD) and catalase (CAT) activities, and total oxidant status (TOS) and malondialdehyde (MDA) levels were increased. Villi were shortened and villus degeneration was observed in ileum of the AA group. Degeneration of surface epithelium and Liberkuhn crypts were observed in colon sections. GSH and TAS levels increased after administration of AA together with crocin, while SOD and CAT levels and TOS and MDA levels decreased; significant recovery of histological damage also was observed. We found that crocin exhibits protective effects on AA induced small and large intestine damage by inhibiting oxidative stress.en_US
dc.description.sponsorshipResearch Fund of the Karabuk University [KBU-BAP-15/2-YL-010]en_US
dc.description.sponsorshipThis work was supported by Research Fund of the Karabuk University [KBU-BAP-15/2-YL-010];en_US
dc.identifier.doi10.1080/10520295.2018.1432888
dc.identifier.endpage276en_US
dc.identifier.issn1052-0295
dc.identifier.issn1473-7760
dc.identifier.issue4en_US
dc.identifier.pmid29644878en_US
dc.identifier.scopus2-s2.0-85045270681en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage267en_US
dc.identifier.urihttps://doi.org/10.1080/10520295.2018.1432888
dc.identifier.urihttps://hdl.handle.net/20.500.14619/5730
dc.identifier.volume93en_US
dc.identifier.wosWOS:000440041100005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofBiotechnic & Histochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectacrylamideen_US
dc.subjectcrocinen_US
dc.subjectlarge intestineen_US
dc.subjectoxidative stressen_US
dc.subjectratsen_US
dc.subjectsmall intestineen_US
dc.titleInvestigation of the protective effects of crocin on acrylamide induced small and large intestine damage in ratsen_US
dc.typeArticleen_US

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