Can crocin play a preventive role in Wistar rats with carbon tetrachloride-induced nephrotoxicity?

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dc.authoridGozukara Bag, Harika Gozde/0000-0003-1208-4072
dc.authoridAltinoz, Eyup/0000-0002-3991-9773
dc.contributor.authorErdemli, Mehmet Erman
dc.contributor.authorGul, Mehmet
dc.contributor.authorAltinoz, Eyup
dc.contributor.authorAksungur, Zeynep
dc.contributor.authorGul, Semir
dc.contributor.authorBag, Harika Gozukara
dc.date.accessioned2024-09-29T16:06:42Z
dc.date.available2024-09-29T16:06:42Z
dc.date.issued2018
dc.departmentKarabük Üniversitesien_US
dc.description.abstractObjective(s): To investigate protective role of crocin by attempting to create nephrotoxicity with carbon tetrachloride. Materials and Methods: Ethics committee approval was obtained and 50 male Wistar rats were randomly divided into 5 groups that included 10 rats each: Control, Corn oil, Crocin, Carbon tetrachloride (CCl4), and Crocin + Carbon tetrachloride. Following the experiments, the rats were decapitated under anesthesia and incised kidney tissues were subjected to biochemical and histological examinations. Results: In the CCl4 administered group, MDA, TOS, Bun, and creatinine levels increased, GSH, SOD, CAT, and TAS levels decreased (P <= 0.05), glomerular collapse in kidney sections, narrowing and local occlusion in Bowman's space in certain glomeruli, inflammatory cell infiltration and congestion were observed when compared to all other groups. There was a significant decrease in increased MDA, TOS, Bun, and creatinine levels, and a significant increase in decreased GSH, SOD, CAT, and TAS levels in CCl4 + crocin administered group compared to the CCl4 group (P <= 0.05), local minimal glomerular damage, tubular damage, inflammatory infiltration, and vascular collagen symptoms were observed in kidney sections, however significant improvement was observed in damage findings when compared to the CCl4 group. Conclusion: At this dose and time interval, against a highly toxic chemical such as CCl4, crocin was able to suppress oxidative stress by playing a protective role in the kidney tissue.en_US
dc.identifier.doi10.22038/IJBMS.2018.26101.6412
dc.identifier.endpage387en_US
dc.identifier.issn2008-3866
dc.identifier.issn2008-3874
dc.identifier.issue4en_US
dc.identifier.pmid29796221en_US
dc.identifier.scopus2-s2.0-85043767006en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage382en_US
dc.identifier.urihttps://doi.org/10.22038/IJBMS.2018.26101.6412
dc.identifier.urihttps://hdl.handle.net/20.500.14619/6999
dc.identifier.volume21en_US
dc.identifier.wosWOS:000433358700006en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMashhad Univ Med Sciencesen_US
dc.relation.ispartofIranian Journal of Basic Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCrocinen_US
dc.subjectCarbon tetrachlorideen_US
dc.subjectKidneyen_US
dc.subjectOxidative stressen_US
dc.subjectRaten_US
dc.titleCan crocin play a preventive role in Wistar rats with carbon tetrachloride-induced nephrotoxicity?en_US
dc.typeArticleen_US

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