Evaluation of sleep quality in patients with ankylosing spondylitis and efficacy of anti-TNF- therapy on sleep problems: A polisomnographic study

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dc.authoridFIRAT, Hikmet/0000-0003-2594-4887
dc.contributor.authorKaratas, Gulsah
dc.contributor.authorBal, Ajda
dc.contributor.authorYuceege, Melike
dc.contributor.authorFirat, Hikmet
dc.contributor.authorGurcay, Eda
dc.contributor.authorArdic, Sadik
dc.contributor.authorCakci, Fatma Aytul
dc.date.accessioned2024-09-29T16:04:32Z
dc.date.available2024-09-29T16:04:32Z
dc.date.issued2018
dc.departmentKarabük Üniversitesien_US
dc.description.abstractIntroductionThis study was conducted to investigate the relationship between sleep quality (SQ) and disease activity (DA) in patients with ankylosing spondylitis (AS) and to evaluate the response to anti-tumor necrosis factor (anti-TNF-) therapy on sleep disorders. Materials and MethodsA total of 34 patients who met the modified New York classification criteria for AS were included in this prospective study. Patients were divided into two groups as follows: Group I (n=15) with high DA and receiving anti-TNF- therapy, and Group II (n=19) in remission. DA was assessed by the Bath AS Disease Activity Index. Pittsburgh Sleep Quality Index (PSQI) and polysomnography (PSG) were used to determine disorders and patterns of sleep, respectively, in both groups at baseline as well as at the third month of anti-TNF- therapy in Group I. ResultsBaseline evaluation revealed impaired SQ in 57.9% of all patients. PSG demonstrated obstructive sleep apnea syndrome, snoring and periodic leg movements in 73.7%, 74.4% and 26.3% of patients, respectively. Prior to anti-TNF- therapy, PSQI and snoring score were significantly higher in Group I (P=0.0001, P=0.012, respectively). Although there was a significant reduction in PSQI scores in Group I (P=0.005) at the third month of anti-TNF- therapy, no change was observed in PSG parameters (P>0.05). ConclusionSleep disorders increase in AS, particularly in patients with high DA. Anti-TNF- therapy has improved SQ without any improvement in PSG. Therefore, it may be concluded that PSG parameters might be more associated with disease pathogenesis rather than DA in patients with AS.en_US
dc.identifier.doi10.1111/1756-185X.13102
dc.identifier.endpage1269en_US
dc.identifier.issn1756-1841
dc.identifier.issn1756-185X
dc.identifier.issue6en_US
dc.identifier.pmid28556500en_US
dc.identifier.scopus2-s2.0-85019748388en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1263en_US
dc.identifier.urihttps://doi.org/10.1111/1756-185X.13102
dc.identifier.urihttps://hdl.handle.net/20.500.14619/6190
dc.identifier.volume21en_US
dc.identifier.wosWOS:000434417500013en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofInternational Journal of Rheumatic Diseasesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectankylosing spondylitisen_US
dc.subjectsleep qualityen_US
dc.subjectsleep disordersen_US
dc.subjectanti-TNF- treatmenten_US
dc.titleEvaluation of sleep quality in patients with ankylosing spondylitis and efficacy of anti-TNF- therapy on sleep problems: A polisomnographic studyen_US
dc.typeArticleen_US

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