Fe3+/SeO42- dual doped nano hydroxyapatite: A novel material for biomedical applications

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dc.authoridPazarceviren, Ahmet Engin/0000-0001-5233-860X
dc.authoridTezcaner, Aysen/0000-0003-4292-5856
dc.authoridAlshemary, Ammar Z/0000-0001-5367-1869
dc.authoridEvis, Zafer/0000-0002-7518-8162
dc.contributor.authorAlshemary, Ammar Z.
dc.contributor.authorPazarceviren, Ahmet Engin
dc.contributor.authorTezcaner, Aysen
dc.contributor.authorEvis, Zafer
dc.date.accessioned2024-09-29T15:50:42Z
dc.date.available2024-09-29T15:50:42Z
dc.date.issued2018
dc.departmentKarabük Üniversitesien_US
dc.description.abstractDual ions substituted hydroxyapatite (HA) received attention from scientists and researchers in the biomedical field owing to their excellent biological properties. This paper presents a novel biomaterial, which holds potential for bone tissue applications. Herein, we have successfully incorporated ferric (Fe3+)/selenate ( SeO42-) ions into the HA structure (Ca10-x-yFey(PO4)(6-x)(SeO4)(x)(OH)(2-x-y)O-y) (Fe-SeHA) through a microwave refluxing process. The Fe-SeHA materials were characterized by X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy, and field emission scanning electron microscopy (FESEM). XRD and FTIR analyses revealed that Fe-SeHA samples were phase pure at 900 degrees C. FESEM images showed that formation of rod-like shaped particles was inhibited dramatically with increasing Fe3+ amount. The Vickers hardness (HV) test showed that hardness values increased with increasing Fe3+ concentrations. Optical spectra of Fe-SeHA materials contained broadband over (200-600) nm. In vitro degradation and bioactivity tests were conducted in simulated body fluid (SBF). The incorporation of Fe3+/ SeO42- ions into the HA structure resulted in a remarkably higher degradation rate along with intense growth of apatite granules on the surface of the Fe-SeHA discs with Ca/P ratio of 1.35-1.47. In vitro protein adsorption assay was conducted in fetal bovine serum (FBS) and it was observed that the adsorption of serum proteins on Fe-SeHA samples significantly increased with increasing Fe3+ concentration. In vitro cytotoxicity tests were performed with human fetal osteoblast (hFOB) cell line and the results demonstrated that hFOB cells attached and proliferated faster on the Fe-SeHA materials compared to pure HA showing that Fe-SeHA materials were cytocompatible. ALP activity and intracellular calcium of hFOB cells on 1Fe-SeHA discs were statistically higher than pure HA, suggesting that presence of Fe3+ ion supported osteogenic differentiation of hFOB cells. Our results suggest that 1Fe-SeHA (0.2M Fe3+/0.5MSeO42- co-doped HA) material could be considered as a promising candidate material for orthopedic applications. (c) 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 340-352, 2018.en_US
dc.description.sponsorshipTUBITAK via 2221 Visiting Scientists Fellowship Programmeen_US
dc.description.sponsorshipDr. Ammar Z. Alshemary would like to thank TUBITAK for providing financial support via 2221 Visiting Scientists Fellowship Programme.en_US
dc.identifier.doi10.1002/jbm.b.33838
dc.identifier.endpage352en_US
dc.identifier.issn1552-4973
dc.identifier.issn1552-4981
dc.identifier.issue1en_US
dc.identifier.pmid28152274en_US
dc.identifier.scopus2-s2.0-85011706630en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage340en_US
dc.identifier.urihttps://doi.org/10.1002/jbm.b.33838
dc.identifier.urihttps://hdl.handle.net/20.500.14619/3696
dc.identifier.volume106en_US
dc.identifier.wosWOS:000417576500035en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Biomedical Materials Research Part B-Applied Biomaterialsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectnovel biomaterialen_US
dc.subjectdual doped HAen_US
dc.subjectFe3+en_US
dc.subjectSeO(4)(2-)ionsen_US
dc.subjectin vitro degradationen_US
dc.subjecthFOB cellsen_US
dc.titleFe3+/SeO42- dual doped nano hydroxyapatite: A novel material for biomedical applicationsen_US
dc.typeArticleen_US

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