Synthesis and sintering of B, Sr, Mg multi-doped hydroxyapatites: Structural, mechanical and biological characterization

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dc.authoridTezcaner, Aysen/0000-0003-4292-5856
dc.authoridYEDEKCI, BUSRA/0000-0003-3378-1950
dc.authoridYilmaz Erdemli, Bengi/0000-0001-7642-4684
dc.authoridDemir, Teyfik/0000-0001-6352-8302
dc.authoridEvis, Zafer/0000-0002-7518-8162
dc.authoridAlshemary, Ammar Z/0000-0001-5367-1869
dc.contributor.authorYedekci, Busra
dc.contributor.authorTezcaner, Aysen
dc.contributor.authorAlshemary, Ammar Z.
dc.contributor.authorYilmaz, Bengi
dc.contributor.authorDemir, Teyfik
dc.contributor.authorEvis, Zafer
dc.date.accessioned2024-09-29T15:57:41Z
dc.date.available2024-09-29T15:57:41Z
dc.date.issued2021
dc.departmentKarabük Üniversitesien_US
dc.description.abstractHydroxyapatite (HA, Ca-10(PO4)(6)(OH)(2)) is the main constituent mineral of bone and teeth in mammals. Due to its outstanding biocompatibility and osteoconductive capabilities, it is preferred for bone repair and replacement. Owing to high potential to have excellent biological properties, ternary ions-doped HAs have just begun to be investigated in the biomedical field and preparing multi-doped HAs is a fairly new approach. Boron (B, BO33-), strontium (Sr, Sr2+) and magnesium (Mg, Mg2+) provide a beneficial effect on bone growth, bone strength, biocompatibility and positively affect bone microstructure. The motivation of this study is taking advantages of the potential of the combine effects of these bivalent ions. In this study, 8 different compositions of BO33- , Sr2+, Mg2+ multi-doped HAs were synthesized by microwave irradiation method to investigate the structural, mechanical and biological features of bone substitutes. This is the first time we report the effect of boron, strontium and magnesium ions multi-doping on the structure of HA and its biological properties. Samples were sintered at 700, 900 and 1100 degrees C. The effect of varying ion contents and sintering temperature on structural and biological properties of the multi-doped samples was investigated. B, Sr and Mg ions were successfully doped into the HA structure according to X-Ray Diffraction (XRD) and Fourier Transform Infrared Spectroscopy (FTIR) analyses. A biphasic structure was obtained with increasing amount of ion-doping. Increasing the sintering temperature affected the crystallinity and the density of the samples gradually. Vicker's microhardness and diametral strength of the samples increased at high sintering temperatures. B-Sr-Mg multi-doped HA promoted osteoblast-like Saos-2 cell proliferation, and as the sintering temperatures of the samples increased, the osteogenic differentiation level of the cultured cells also increased. Overall, results showed that the biological properties of HA were improved with the doping of Sr, Mg and B ions, and for bone implant applications samples sintered at 1100 degrees C were suggested to have potential as a biomaterial.en_US
dc.description.sponsorshipTUBITAK [217M264]en_US
dc.description.sponsorshipThis study has been financially supported by TUBITAK under the project number 217M264.en_US
dc.identifier.doi10.1016/j.jmbbm.2020.104230
dc.identifier.issn1751-6161
dc.identifier.issn1878-0180
dc.identifier.pmid33307486en_US
dc.identifier.scopus2-s2.0-85097578992en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1016/j.jmbbm.2020.104230
dc.identifier.urihttps://hdl.handle.net/20.500.14619/4959
dc.identifier.volume115en_US
dc.identifier.wosWOS:000618732200007en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofJournal of the Mechanical Behavior of Biomedical Materialsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHydroxyapatiteen_US
dc.subjectB-Sr-Mg-Hoped hydroxyapatiteen_US
dc.subjectStructural analysisen_US
dc.subjectBiological propertiesen_US
dc.subjectVickers hardnessen_US
dc.titleSynthesis and sintering of B, Sr, Mg multi-doped hydroxyapatites: Structural, mechanical and biological characterizationen_US
dc.typeArticleen_US

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