Antioxidant and anti-inflammatory potential of crocin on the doxorubicin mediated hepatotoxicity in Wistar rats

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dc.authoridAltinoz, Eyup/0000-0002-3991-9773
dc.authoridDEMIR, MEHMET/0000-0001-6990-3337
dc.contributor.authorDemir, M.
dc.contributor.authorAltinoz, E.
dc.contributor.authorKoca, O.
dc.contributor.authorElbe, H.
dc.contributor.authorOnal, M. O.
dc.contributor.authorBicer, Y.
dc.contributor.authorKarayakali, M.
dc.date.accessioned2024-09-29T16:00:49Z
dc.date.available2024-09-29T16:00:49Z
dc.date.issued2023
dc.departmentKarabük Üniversitesien_US
dc.description.abstractDoxorubicin (DXR) is widely used in cancer treatment. However, it has not yet been possible to prevent the side effects of DXR. The aim of this study was to investigate the hepatoprotective effect of crocin against DXR used in cancer treatment. For this reason; forty Wistar rats (male-250-300 g) were allocated into four groups (n = 10/ group): Control, Crocin, DXR and DXR+Crocin. Control and Crocin groups were administered saline and crocin (40 mg/kg, i.p) for 15 days, respectively. DXR group, cumulative dose 12 mg/kg DXR, was administered for 12 days via 48 h intervals in six injections (2 mg/kg each, i.p). DXR+Crocin group, crocin (40 mg/kg-i.p) was administered for 15 days, and DXR was given as in the DXR group. The results revealed that serum liver markers (alanine transaminase (ALT), aspartate transaminase (AST), and alkaline phosphatase (ALP) increased significantly after DXR administration but recovered after crocin therapy. In addition, lipid peroxidation (MDA), and inflammatory cytokine (TNF-& alpha;) increased after DXR application and the antioxidative defense system (GSH, SOD, CAT) significantly decreased and re-achieved by crocin treatment. Our results conclude that crocin treatment was related to ameliorated hepatocellular architecture and reduced hepatic oxidative stress and inflammation in rats with DXR-induced hepatotoxicity.en_US
dc.identifier.doi10.1016/j.tice.2023.102182
dc.identifier.issn0040-8166
dc.identifier.pmid37523948en_US
dc.identifier.scopus2-s2.0-85166174273en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1016/j.tice.2023.102182
dc.identifier.urihttps://hdl.handle.net/20.500.14619/5378
dc.identifier.volume84en_US
dc.identifier.wosWOS:001051381500001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherChurchill Livingstoneen_US
dc.relation.ispartofTissue & Cellen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDoxorubicinen_US
dc.subjectCrocinen_US
dc.subjectLiver damageen_US
dc.subjectTumor necrosis factor-alphaen_US
dc.subjectSuperoxide dismutaseen_US
dc.subjectMalondialdehydeen_US
dc.titleAntioxidant and anti-inflammatory potential of crocin on the doxorubicin mediated hepatotoxicity in Wistar ratsen_US
dc.typeArticleen_US

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