A Brief Critique of the TATES Procedure

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dc.authoridKuperman, Samuel/0000-0002-5995-1981
dc.authoridSalvatore, Jessica/0000-0001-5504-5087
dc.contributor.authorAliev, Fazil
dc.contributor.authorSalvatore, Jessica E.
dc.contributor.authorAgrawal, Arpana
dc.contributor.authorAlmasy, Laura
dc.contributor.authorChan, Grace
dc.contributor.authorEdenberg, Howard J.
dc.contributor.authorHesselbrock, Victor
dc.date.accessioned2024-09-29T15:51:12Z
dc.date.available2024-09-29T15:51:12Z
dc.date.issued2018
dc.departmentKarabük Üniversitesien_US
dc.description.abstractThe Trait-based test that uses the Extended Simes procedure (TATES) was developed as a method for conducting multivariate GWAS for correlated phenotypes whose underlying genetic architecture is complex. In this paper, we provide a brief methodological critique of the TATES method using simulated examples and a mathematical proof. Our simulated examples using correlated phenotypes show that the Type I error rate is higher than expected, and that more TATES p values fall outside of the confidence interval relative to expectation. Thus the method may result in systematic inflation when used with correlated phenotypes. In a mathematical proof we further demonstrate that the distribution of TATES p values deviates from expectation in a manner indicative of inflation. Our findings indicate the need for caution when using TATES for multivariate GWAS of correlated phenotypes.en_US
dc.description.sponsorshipNIH [U10AA008401]; TUBITAK, Turkey [114C117]; [F32AA022269]; [K01AA024152]; [K02AA018755]; [DA32573]en_US
dc.description.sponsorshipThis work was supported in part by funding for The Collaborative Study on the Genetics of Alcoholism, NIH Grant U10AA008401. This work was also supported by F32AA022269 and K01AA024152 (Salvatore); TUBITAK, Turkey, Grant #114C117 (Aliev); K02AA018755 (Dick); and DA32573 (Agrawal). This publication is solely the responsibility of the authors and does not necessarily represent the official view of the funders.en_US
dc.identifier.doi10.1007/s10519-018-9890-6
dc.identifier.endpage167en_US
dc.identifier.issn0001-8244
dc.identifier.issn1573-3297
dc.identifier.issue2en_US
dc.identifier.pmid29468442en_US
dc.identifier.scopus2-s2.0-85042230410en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage155en_US
dc.identifier.urihttps://doi.org/10.1007/s10519-018-9890-6
dc.identifier.urihttps://hdl.handle.net/20.500.14619/3927
dc.identifier.volume48en_US
dc.identifier.wosWOS:000426557700006en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofBehavior Geneticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMultivariate GWASen_US
dc.subjectComplex traitsen_US
dc.subjectTATESen_US
dc.titleA Brief Critique of the TATES Procedureen_US
dc.typeArticleen_US

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