Spectral analysis and biological activity assessment of silver doped hydroxyapatite

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dc.authoridErdem, Umit/0000-0002-0480-8176
dc.authoridBozer, Busra/0000-0002-7280-4417
dc.contributor.authorErdem, Umit
dc.contributor.authorBozer, Busra Moran
dc.contributor.authorTurkoz, Mustafa B.
dc.contributor.authorMetin, Aysegul U.
dc.contributor.authorYildirim, Gurcan
dc.contributor.authorTurk, Mustafa
dc.contributor.authorNezir, Saffet
dc.date.accessioned2024-09-29T16:03:01Z
dc.date.available2024-09-29T16:03:01Z
dc.date.issued2021
dc.departmentKarabük Üniversitesien_US
dc.description.abstractIn this study, the hydroxyapatite biomaterials are produced by the precipitation method and the role of silver doping within the different molar ratios of 2.0, 5.0, and 10.0% are investigated with some fundamental analysis, including powder XRD, SEM, EDS, FTIR, Raman, and material densities. In vitro biocompatibility assessment is conducted with cytotoxicity and agar diffusion tests. Moreover, genotoxicity tests determine whether the biomaterials produced cause the mutations or not. In addition, a hemolytic effect test examines the variation of hemolytic behavior of compounds. Also, the cell migration experiments inspect the influence of silver ion levels in biomaterials on many biological processes. The experimental results reveal that the honeycomb-patterned morphological structures are obtained for all the products. FTIR and Raman analyses reveal that the dramatic changes in the characteristic functional group peaks are obtained with the increment in the amount of silver ions. The experimental parts related to the biocompatibility assessment of the study show that there seems to be deterioration in biocompatibility as the silver ion-doping level increases in the system. To sum up, the ideal doping value for bone tissue engineering applications is found to be 2%.en_US
dc.identifier.doi10.1080/21870764.2021.1989749
dc.identifier.endpage1545en_US
dc.identifier.issn2187-0764
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85117349655en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1524en_US
dc.identifier.urihttps://doi.org/10.1080/21870764.2021.1989749
dc.identifier.urihttps://hdl.handle.net/20.500.14619/5843
dc.identifier.volume9en_US
dc.identifier.wosWOS:000708270000001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofJournal of Asian Ceramic Societiesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHydroxyapatiteen_US
dc.subjectsilver dopingen_US
dc.subjectbiocompabilityen_US
dc.subjectcell migrationen_US
dc.titleSpectral analysis and biological activity assessment of silver doped hydroxyapatiteen_US
dc.typeArticleen_US

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