Comparison of effectiveness of intravitreal ranibizumab and dexamethasone in branch retinal vein occlusion
Küçük Resim Yok
Tarih
2020
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Gazi Eye Foundation
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Purpose: Comparison of intravitreal ranibizumab (IVR) and dexamethasone (IVD) effectiveness in branch retinal vein occlusion (BRVO) Materials and Methods: Fifty-five patients with BRVO and macular edema were treated with IVR (Group 1) in 32 patients and IVD (Group 2) in 23 patients. Groups were compared regarding age, gender, ischemia, duration of post-edema application, number of intravitreal injections. Intraocular pressures (IOP), central macular thickness (CMT) and logarithmic visual acuity (LVA) values were evaluated before injection and at months 1, 3 and 6 after injection. Statistical analyses were performed by SPSS 16.0. Results: Ischemia was present in 8 patients in group 1 and 13 patients in group 2 (p = 0.005). The mean number of injections was 2.41 ± 1.15 in group 1 and 1.66 ± 0.48 in group 2 (p = 0.007). The IOP was significantly higher at month 6 in group 1 (p = 0.018) and at month 3 in group 2 (p = 0.049). There was no statistical difference between LVA 3 and LVA 6 in group 1 (p=0.238). Among other parameters, there was significantly higher visual acuity level (p <0.05) with improvements up to 6 months. Although there was no statistical difference between LVA 1 and LVA 3 (p = 0.097) and between LVA 3 and LVA 6 (p = 0.397) in group 2, the visual acuity was progressively improved until month 6. There was statistically significant difference among other CMT values (p <0.05), although there was no statistical difference between CMT 3 and CMT 6 in Group 1 (p = 0.238). In group 2, there was no significant difference between CMT 1 and CMT 6 or CMT 3 and CMT 6 (p values 0.985, 0.414) but there were significant differences among other CMT values w (P <0.05). Conclusion: The intraocular pressure was found to be elevated in IVR group at month 6 and in IVD group at month 3. LVA remained low until month 6. While CMT was progressively decreased in the IVR group until month 6, it was decreased at month 1 followed by elevation at month 3 and further decreased at month 6 in the IVD group. © 2019 Gazi Eye Foundation. All rights reserved.
Açıklama
Anahtar Kelimeler
Branch vein occlusion, Dexamethasone implant, Intravitreal injection, Ranibizumab
Kaynak
Retina-Vitreus
WoS Q Değeri
Scopus Q Değeri
Q4
Cilt
28
Sayı
1
