Silver release of Ag (I) doped hydroxyapatite: In vitro study

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dc.authoridErdem, Umit/0000-0002-0480-8176
dc.contributor.authorErdem, Umit
dc.contributor.authorTurkoz, Mustafa B.
dc.date.accessioned2024-09-29T15:50:43Z
dc.date.available2024-09-29T15:50:43Z
dc.date.issued2019
dc.departmentKarabük Üniversitesien_US
dc.description.abstractA material is produced by doping of silver (Ag (I)) which has antibacterial property to nano hydroxyapatite (nHAp), to remove the hipersensitivity in the teeth by closing the dentine tubules or dental micro cracks of the teeth and effective against for some bacteria. The doping of Ag (I) can also produces a toxic effect. Ag (I) can be released from the structure as a result of biological, physical and chemical effects and may cause toxicity. Therefore, it is important to determine whether the presence of Ag (I) has a toxic effect. In this study, Ag (I)-doped nHAp was synthesized by precipitation method and tried to determine the release values as a function of time compared to the doping rate by using the ICP-OES. Also, the products we produce in simulated body fluid were kept for retention periods of 4-20 weeks to determine degradation percentages. A cytotoxicity study was performed to observe the toxic effect that may be caused by possible Ag (I) release. According to the analysis, the release values in all products were observed in ppb level. And it is concluded that the materials produced are not degraded. Cell viability values of more than 70% were obtained. It was observed that the release of Ag (I) bound to Ag (I)-doped nHAp hexagonal structure was very low. It was concluded that the products are not degraded and Ag (I)-doped nHAp to a certain ratio is a biocompatible material that can be used in dentistry for treatment.en_US
dc.identifier.doi10.1002/jemt.23243
dc.identifier.endpage971en_US
dc.identifier.issn1059-910X
dc.identifier.issn1097-0029
dc.identifier.issue7en_US
dc.identifier.pmid30901135en_US
dc.identifier.scopus2-s2.0-85063283580en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage961en_US
dc.identifier.urihttps://doi.org/10.1002/jemt.23243
dc.identifier.urihttps://hdl.handle.net/20.500.14619/3703
dc.identifier.volume82en_US
dc.identifier.wosWOS:000471903000002en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofMicroscopy Research and Techniqueen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectcytotoxicityen_US
dc.subjectdegredationen_US
dc.subjecthydroxyapatiteen_US
dc.subjectsilver releaseen_US
dc.titleSilver release of Ag (I) doped hydroxyapatite: In vitro studyen_US
dc.typeArticleen_US

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