A novel method to identify and grade DNA damage on comet images

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dc.contributor.authorTuran, Muhammed Kamil
dc.contributor.authorSehirli, Eftal
dc.date.accessioned2024-09-29T15:55:09Z
dc.date.available2024-09-29T15:55:09Z
dc.date.issued2017
dc.departmentKarabük Üniversitesien_US
dc.description.abstractBackground and objective: In recent years, development of software programs in medicine field has proceeded in a rapid manner. Comet assay is one of the research methods in medicine field that displays whether DNA has damage. In this study, it is aimed to share experience of dynamic time warping method and decision tree to decide whether DNA has damage and grade DNA damage by means of the software program. Methods: The application analyzes manually extracted RGB single comet images whose centers are manually marked. The application performs pixel profile analysis at the directions of vertical and horizontal based on the center of comet. The bidirectional pixel profile results are used as inputs of dynamic time warping. Four novel and one conventional measurement parameters some of which are calculated by dynamic time warping are given to decision tree. Results: The decision tree identifies whether DNA has damage and grades DNA damage categorizing four damage levels with accuracy of 99.03% using only two of five measurement parameters. Conclusions: This paper mainly focuses on features and usage of dynamic time warping and decision tree as a novel method to identify and grade DNA damage on comet images. (C) 2017 Elsevier B.V. All rights reserved.en_US
dc.identifier.doi10.1016/j.cmpb.2017.06.002
dc.identifier.endpage27en_US
dc.identifier.issn0169-2607
dc.identifier.issn1872-7565
dc.identifier.pmid28734527en_US
dc.identifier.scopus2-s2.0-85021157564en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage19en_US
dc.identifier.urihttps://doi.org/10.1016/j.cmpb.2017.06.002
dc.identifier.urihttps://hdl.handle.net/20.500.14619/4498
dc.identifier.volume147en_US
dc.identifier.wosWOS:000407522700004en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Ireland Ltden_US
dc.relation.ispartofComputer Methods and Programs in Biomedicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCometen_US
dc.subjectImage processingen_US
dc.subjectDecision treeen_US
dc.subjectDNA damageen_US
dc.subjectDynamic time warpingen_US
dc.titleA novel method to identify and grade DNA damage on comet imagesen_US
dc.typeArticleen_US

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