Impact of synaptic noise and conductance state on spontaneous cortical firing

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dc.authoridERKAYMAZ, OKAN/0000-0002-1996-8623
dc.contributor.authorOzer, Mahmut
dc.contributor.authorGraham, Lyle J.
dc.contributor.authorErkaymaz, Okan
dc.contributor.authorUzuntarla, Muhammet
dc.date.accessioned2024-09-29T16:03:12Z
dc.date.available2024-09-29T16:03:12Z
dc.date.issued2007
dc.departmentKarabük Üniversitesien_US
dc.description.abstractCortical neurons in-vivo operate in a continuum of overall conductance states, depending on the average level of background synaptic input throughout the dendritic tree. We compare how variability, or fluctuations, in this input affects the statistics of the resulting 'spontaneous' or 'background' firing activity, between two extremes of the mean input corresponding to a low-conductance (LC) and a high-conductance (HC) state. In the HC state, we show that both firing rate and regularity increase with increasing variability. In the LC state, firing rate also increases with input variability, but in contrast to the HC state, firing regularity first decreases and then increases with an increase in the variability. At high levels of input variability, firing regularity in both states converge to similar values.en_US
dc.identifier.doi10.1097/WNR.0b013e328277ef8a
dc.identifier.endpage1374en_US
dc.identifier.issn0959-4965
dc.identifier.issn1473-558X
dc.identifier.issue13en_US
dc.identifier.pmid17762715en_US
dc.identifier.scopus2-s2.0-34548305057en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1371en_US
dc.identifier.urihttps://doi.org/10.1097/WNR.0b013e328277ef8a
dc.identifier.urihttps://hdl.handle.net/20.500.14619/5955
dc.identifier.volume18en_US
dc.identifier.wosWOS:000248982300014en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofNeuroreporten_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectconductance statesen_US
dc.subjectcortical neuronen_US
dc.subjectspike regularityen_US
dc.subjectsynaptic background activityen_US
dc.titleImpact of synaptic noise and conductance state on spontaneous cortical firingen_US
dc.typeArticleen_US

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