Associations between neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, albuminuria and uric acid and the estimated glomerular filtration rate in hypertensive patients with chronic kidney disease stages 1-3

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dc.contributor.authorSevencan, Nurhayat Ozkan
dc.contributor.authorOzkan, Aysegul Ertinmaz
dc.date.accessioned2024-09-29T16:09:37Z
dc.date.available2024-09-29T16:09:37Z
dc.date.issued2019
dc.departmentKarabük Üniversitesien_US
dc.description.abstractIntroduction: The neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), albuminuria and uric acid are known to be independent predictors of hypertension and cardiovascular mortality. However, to date, no study has been conducted describing the relationships between the NLR, PLR and estimated glomerular filtration rate (eGFR) in hypertensive patients with chronic kidney disease (CKD) who do not require renal replacement therapy. Material and methods: This prospective study included 271 patients with essential hypertension and eGFR >= 30 ml/min/1.73 m(2). The patients were divided into two groups: those with CKD stages 1 and 2 and those with stage 3. We used the complete blood count to calculate the NLR and PLR, and we measured the albuminuria and uric acid levels. Then, we studied their associations with the eGFR and their potential uses as independent risk factors for renal damage. Results: The NLR, albuminuria and uric acid were higher in patients with CKD stage 3 than in those with stages 1 and 2 (p = 0.013, p = 0.001 and p = 0.001, respectively). However, no significant difference was detected in the PLR. In stage 3 patients, albuminuria and uric acid were found to be independent risk factors affecting the eGFR (p = 0.042 and p = 0.001, respectively). However, the effects of the NLR and PLR on the eGFR were not significant (p = 0.104 and p = 0.578, respectively). Conclusions: The NLR, similar to albuminuria and uric acid, the NLR was found to be a specific marker for CKD stage 3 patients. However, the NLR and PLR did not act as independent risk factors affecting the eGFR.en_US
dc.identifier.doi10.5114/aoms.2018.76262
dc.identifier.endpage1239en_US
dc.identifier.issn1734-1922
dc.identifier.issn1896-9151
dc.identifier.issue5en_US
dc.identifier.pmid31572468en_US
dc.identifier.scopus2-s2.0-85072189414en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1232en_US
dc.identifier.urihttps://doi.org/10.5114/aoms.2018.76262
dc.identifier.urihttps://hdl.handle.net/20.500.14619/7684
dc.identifier.volume15en_US
dc.identifier.wosWOS:000484782500014en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTermedia Publishing House Ltden_US
dc.relation.ispartofArchives of Medical Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectneutrophil/lymphocyte ratioen_US
dc.subjectplatelet/lymphocyte ratioen_US
dc.subjecturic aciden_US
dc.subjectalbuminuriaen_US
dc.subjectestimated glomerular filtration rateen_US
dc.subjectchronic kidney diseaseen_US
dc.titleAssociations between neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, albuminuria and uric acid and the estimated glomerular filtration rate in hypertensive patients with chronic kidney disease stages 1-3en_US
dc.typeArticleen_US

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