Can Genetics Predict Response to Complex Behavioral Interventions? Evidence from a Genetic Analysis of the Fast Track Randomized Control Trial

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dc.authoridBelsky, Daniel/0000-0001-5463-2212
dc.authoridMcMahon, Robert/0000-0002-4034-5818
dc.authoridCrowley, Max/0000-0001-8956-3456
dc.contributor.authorAlbert, Dustin
dc.contributor.authorBelsky, Daniel W.
dc.contributor.authorCrowley, D. Max
dc.contributor.authorLatendresse, Shawn J.
dc.contributor.authorAliev, Fazil
dc.contributor.authorRiley, Brien
dc.contributor.authorSun, Cuie
dc.date.accessioned2024-09-29T15:50:50Z
dc.date.available2024-09-29T15:50:50Z
dc.date.issued2015
dc.departmentKarabük Üniversitesien_US
dc.description.abstractEarly interventions are a preferred method for addressing behavioral problems in high-risk children, but often have only modest effects. Identifying sources of variation in intervention effects can suggest means to improve efficiency. One potential source of such variation is the genome. We conducted a genetic analysis of the Fast Track randomized control trial, a 10-year-long intervention to prevent high-risk kindergarteners from developing adult externalizing problems including substance abuse and antisocial behavior. We tested whether variants of the glucocorticoid receptor gene NR3C1 were associated with differences in response to the Fast Track intervention. We found that in European-American children, a variant of NR3C1 identified by the single-nucleotide polymorphism rs10482672 was associated with increased risk for externalizing psychopathology in control group children and decreased risk for externalizing psychopathology in intervention group children. Variation in NR3C1 measured in this study was not associated with differential intervention response in African-American children. We discuss implications for efforts to prevent externalizing problems in high-risk children and for public policy in the genomic era.en_US
dc.description.sponsorshipNICHD [HD007376-22]; NIDA [DA16903, DA015226, DA017589, DA023026]; NIA [AG000029]; National Institute of Mental Health (NIMH) [R18 MH48043, R18 MH50951, R18 MH50952, R18 MH50953]; National Institute on Drug Abuse (NIDA) [1 RC1 DA028248-01]; Center for Substance Abuse Prevention; Department of Education [S184U30002]; NIMH [K05MH00797, K05MH01027]en_US
dc.description.sponsorshipD.A. was supported in part by NICHD HD007376-22 and NIDA DA16903. D.W.B. was supported in part by NIA AG000029. The Fast Track project was supported by National Institute of Mental Health (NIMH) grants R18 MH48043, R18 MH50951, R18 MH50952, R18 MH50953, and by National Institute on Drug Abuse (NIDA) grant 1 RC1 DA028248-01. The Center for Substance Abuse Prevention and NIDA also provided support for Fast Track through a memorandum of agreement with the NIMH. This work was also supported in part by Department of Education grant S184U30002; NIMH grants K05MH00797 and K05MH01027; and NIDA grants DA16903, DA015226, DA017589, and DA023026. Dr. Greenberg is an author of the PATHS curriculum and has a royalty agreement with Channing-Bete, Inc. Dr. Greenberg is a principal in PATHS Training, LLC. Dr. McMahon is a co-author of helping the noncompliant child and has a royalty agreement with Guilford Publications, Inc.; he is also a member of the Treatments That Work Scientific Advisory Board with Oxford University Press. The other authors have no financial relationships to disclose.en_US
dc.identifier.doi10.1002/pam.21811
dc.identifier.endpageU206en_US
dc.identifier.issn0276-8739
dc.identifier.issn1520-6688
dc.identifier.issue3en_US
dc.identifier.pmid26106668en_US
dc.identifier.scopus2-s2.0-84930573872en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage497en_US
dc.identifier.urihttps://doi.org/10.1002/pam.21811
dc.identifier.urihttps://hdl.handle.net/20.500.14619/3728
dc.identifier.volume34en_US
dc.identifier.wosWOS:000356005100004en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Policy Analysis and Managementen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectGlucocorticoid-Receptor Geneen_US
dc.subjectDifferential Susceptibilityen_US
dc.subjectEnvironment Interactionen_US
dc.subjectExternalizing Behavioren_US
dc.subjectAlcohol-Useen_US
dc.subjectLife-Courseen_US
dc.subjectStressen_US
dc.subjectPolymorphismsen_US
dc.subjectPreventionen_US
dc.subjectVariantsen_US
dc.titleCan Genetics Predict Response to Complex Behavioral Interventions? Evidence from a Genetic Analysis of the Fast Track Randomized Control Trialen_US
dc.typeArticleen_US

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