Treatment with crocin suppresses diabetic nephropathy progression via modulating TGF-81 and oxidative stress in an experimental model of pinealectomized diabetic rats

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dc.authoridAltinoz, Eyup/0000-0002-3991-9773
dc.contributor.authorKeelo, Rihab Mudhafar Ali Hammood
dc.contributor.authorElbe, Hulya
dc.contributor.authorBicer, Yasemin
dc.contributor.authorYigitturk, Gurkan
dc.contributor.authorKoca, Oguzhan
dc.contributor.authorKarayakali, Melike
dc.contributor.authorAcar, Derya
dc.date.accessioned2024-09-29T15:55:05Z
dc.date.available2024-09-29T15:55:05Z
dc.date.issued2022
dc.departmentKarabük Üniversitesien_US
dc.description.abstractOne of the most common complications of diabetes is diabetic nephropathy (DN). Uncontrolled hyperglycemia leads to histopathologic alterations in the kidney that prevent normal renal function. This study aimed to explore the effects of crocin treatment via virtue of its numerous beneficial properties in streptozotocin-induced pinealectomized diabetic rats. The pinealectomy procedure was conducted on the first day of the study. On the 30th day following pinealectomy, streptozotocin (STZ) (50 mg/kg) was administered intraperitoneally in Wistar rats for induction of diabetes. Diabetes was confirmed on the 3rd day following STZ administration by determining the glucose levels. Daily crocin treatment intraperitoneally for 15 days (50 mg/kg) ameliorated impaired renal oxidant/antioxidant balance, reduced TGF-81 immuno-staining around tubules, and promoted improvement of renal architecture. Moreover, crocin administration improved altered renal function parameters, including serum Cr and BUN, and also increased creatinine clearance. In conclusion, the protective effects of crocin on diabetic nephropathy might be associated with its powerful antioxidant properties, its ability to improve tissue antioxidant status, and its ability to prevent inflammatory pathways.en_US
dc.description.sponsorshipResearch Fund of the Karabuk Univer-sity [TYL-2020-2350]en_US
dc.description.sponsorshipThis work was supported by Research Fund of the Karabuk Univer-sity (TYL-2020-2350) .en_US
dc.identifier.doi10.1016/j.cbi.2021.109733
dc.identifier.issn0009-2797
dc.identifier.issn1872-7786
dc.identifier.scopus2-s2.0-85118331319en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1016/j.cbi.2021.109733
dc.identifier.urihttps://hdl.handle.net/20.500.14619/4459
dc.identifier.volume351en_US
dc.identifier.wosWOS:000721106500005en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevier Ireland Ltden_US
dc.relation.ispartofChemico-Biological Interactionsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPinealectomyen_US
dc.subjectDiabetesen_US
dc.subjectCrocinen_US
dc.subjectMDAen_US
dc.subjectTGF-81en_US
dc.subjectROSen_US
dc.titleTreatment with crocin suppresses diabetic nephropathy progression via modulating TGF-81 and oxidative stress in an experimental model of pinealectomized diabetic ratsen_US
dc.typeArticleen_US

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