Shared genetic risk between eating disorder- and substance-use-related phenotypes: Evidence from genome-wide association studies

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dc.authoridPantel, Jacques/0000-0002-9015-6281
dc.authoridHartz, Sarah/0000-0002-5429-3799
dc.authoridNothen, Markus/0000-0002-8770-2464
dc.authoridLahti-Pulkkinen, Marius/0000-0002-5244-5525
dc.authoridHinney, Anke/0000-0001-5659-0706
dc.authoridBreen, Gerome/0000-0003-2053-1792
dc.authoridKaprio, Jaakko/0000-0002-3716-2455
dc.contributor.authorMunn-Chernoff, Melissa A.
dc.contributor.authorJohnson, Emma C.
dc.contributor.authorChou, Yi-Ling
dc.contributor.authorColeman, Jonathan R. I.
dc.contributor.authorThornton, Laura M.
dc.contributor.authorWalters, Raymond K.
dc.contributor.authorYilmaz, Zeynep
dc.date.accessioned2024-09-29T16:04:33Z
dc.date.available2024-09-29T16:04:33Z
dc.date.issued2021
dc.departmentKarabük Üniversitesien_US
dc.description.abstractEating disorders and substance use disorders frequently co-occur. Twin studies reveal shared genetic variance between liabilities to eating disorders and substance use, with the strongest associations between symptoms of bulimia nervosa and problem alcohol use (genetic correlation [r(g)], twin-based = 0.23-0.53). We estimated the genetic correlation between eating disorder and substance use and disorder phenotypes using data from genome-wide association studies (GWAS). Four eating disorder phenotypes (anorexia nervosa [AN], AN with binge eating, AN without binge eating, and a bulimia nervosa factor score), and eight substance-use-related phenotypes (drinks per week, alcohol use disorder [AUD], smoking initiation, current smoking, cigarettes per day, nicotine dependence, cannabis initiation, and cannabis use disorder) from eight studies were included. Significant genetic correlations were adjusted for variants associated with major depressive disorder and schizophrenia. Total study sample sizes per phenotype ranged from similar to 2400 to similar to 537 000 individuals. We used linkage disequilibrium score regression to calculate single nucleotide polymorphism-based genetic correlations between eating disorder- and substance-use-related phenotypes. Significant positive genetic associations emerged between AUD and AN (r(g) = 0.18; false discovery rate q = 0.0006), cannabis initiation and AN (r(g) = 0.23; q < 0.0001), and cannabis initiation and AN with binge eating (r(g) = 0.27; q = 0.0016). Conversely, significant negative genetic correlations were observed between three nondiagnostic smoking phenotypes (smoking initiation, current smoking, and cigarettes per day) and AN without binge eating (r(gs) = -0.19 to -0.23; qs < 0.04). The genetic correlation between AUD and AN was no longer significant after co-varying for major depressive disorder loci. The patterns of association between eating disorder- and substance-use-related phenotypes highlights the potentially complex and substance-specific relationships among these behaviors.en_US
dc.description.sponsorshipEunice Kennedy Shriver National Institute of Child Health and Human Development [R01HD093651] Funding Source: NIH RePORTER; National Institute of General Medical Sciences [R01GM126479] Funding Source: NIH RePORTER; National Institute of Mental Health [R01MH123619] Funding Source: NIH RePORTER; National Institute on Alcohol Abuse and Alcoholism [K01AA025113] Funding Source: NIH RePORTER; National Institute on Drug Abuse [K02DA032573] Funding Source: NIH RePORTER; MRC [MC_UU_00007/10] Funding Source: UKRIen_US
dc.identifier.doi10.1111/adb.12880
dc.identifier.issn1355-6215
dc.identifier.issn1369-1600
dc.identifier.issue1en_US
dc.identifier.pmid32064741en_US
dc.identifier.scopus2-s2.0-85079714981en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1111/adb.12880
dc.identifier.urihttps://hdl.handle.net/20.500.14619/6201
dc.identifier.volume26en_US
dc.identifier.wosWOS:000513571200001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofAddiction Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjecteating disordersen_US
dc.subjectgenetic correlationen_US
dc.subjectsubstance useen_US
dc.titleShared genetic risk between eating disorder- and substance-use-related phenotypes: Evidence from genome-wide association studiesen_US
dc.typeArticleen_US

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