THE EFFECT OF SAFFRON (ITS ACTIVE CONSTITUENT, CROCIN) ON THE CARDIOVASCULAR COMPLICATION AND DYSLIPIDEMIA IN STREPTOZOTOCIN INDUCED DIABETIC RATS

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dc.authoridAltinoz, Eyup/0000-0002-3991-9773
dc.contributor.authorAltinoz, Eyup
dc.contributor.authorTaskin, Emre
dc.contributor.authorOner, Zulal
dc.contributor.authorElbe, Hulya
dc.contributor.authorArslan, Belkis Atasever
dc.date.accessioned2024-09-29T16:08:34Z
dc.date.available2024-09-29T16:08:34Z
dc.date.issued2015
dc.departmentKarabük Üniversitesien_US
dc.description.abstractBackground: Diabetes mellitus (DM) causes serious complications such as coronary heart disease, atherosclerosis, nephropathy, retinopathy and neuropathy. Materials and Methods: Rats were randomly divided into three groups, each containing 10 rats: control group, DM group; DM+crocin group. Normal saline was administered in the control and DM groups, and crocin was administered in DM+crocin group at a dose of 20 mg/kg bw/day for 21 days. Trunk blood and the hearth tissue were collected for histopathological and biochemical examination. Results: DM led to increment of MDA levels (p<0.05) and the serum levels of total cholesterol, TG, LDL and VLDL (p<0.05) and decrease of GSH levels (p<0.01) compared to control group in serum and heart tissue. Diabetic rats were treated with crocin, MDA levels (p<0.05) and the levels of total cholesterol, TG and VLDL decreased significantly, but GSH levels (p<0.05) increased remarkably compared to DM rats. Statistically significant increase in histopathological damage score was found in the DM group (p<0.0001). Histopathological changes markedly regressed in DM+crocin group. Conclusion: Our results showed that crocin might prevent diabetes induced cardiovascular complications by reduction of oxidative stress and dyslipidemia.en_US
dc.identifier.doi10.4314/ajtcam.v12i5.1
dc.identifier.endpage7en_US
dc.identifier.issn0189-6016
dc.identifier.issue5en_US
dc.identifier.scopus2-s2.0-84965146429en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://doi.org/10.4314/ajtcam.v12i5.1
dc.identifier.urihttps://hdl.handle.net/20.500.14619/7622
dc.identifier.volume12en_US
dc.identifier.wosWOS:000372327600001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherAfrican Networks Ethnomedicinesen_US
dc.relation.ispartofAfrican Journal of Traditional Complementary and Alternative Medicinesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectOxidative stressen_US
dc.subjectMDAen_US
dc.subjectGSHen_US
dc.subjectcrocinen_US
dc.subjectDiabetesen_US
dc.subjectdislipidemiaen_US
dc.titleTHE EFFECT OF SAFFRON (ITS ACTIVE CONSTITUENT, CROCIN) ON THE CARDIOVASCULAR COMPLICATION AND DYSLIPIDEMIA IN STREPTOZOTOCIN INDUCED DIABETIC RATSen_US
dc.typeArticleen_US

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