Effects of pinealectomy and crocin treatment on rats with isoproterenol-induced myocardial infarction

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dc.authoridDEMIR, MEHMET/0000-0001-6990-3337
dc.authoridAltinoz, Eyup/0000-0002-3991-9773
dc.contributor.authorDemir, Mehmet
dc.contributor.authorAltinoz, Eyup
dc.contributor.authorElbe, Hulya
dc.contributor.authorBicer, Yasemin
dc.contributor.authorYigitturk, Gurkan
dc.contributor.authorKarayakali, Melike
dc.contributor.authorBallur, Arwa Fadil Haqi
dc.date.accessioned2024-09-29T16:01:16Z
dc.date.available2024-09-29T16:01:16Z
dc.date.issued2022
dc.departmentKarabük Üniversitesien_US
dc.description.abstractThe present study aimed to analyze the effects of pinealectomy and crocin treatment in isoproterenol-induced myocardial damage. Seventy rats were divided into seven groups: control, sham control, pinealectomy (PNX), isoproterenol (ISO; 85 mg/kg on the 29th and 30th days of the experiment, subcutaneous injection), PNX + ISO, PNX + crocin (50 mg/kg/day for 30 days, intragastric administration), and PNX + ISO + crocin. PNX procedure was performed on the first day of the study. A significant increase was observed in serum cardiac damage markers (CK-MB, Troponin I) after ISO administration. ISO administration led to a significant increase in cardiac oxidative stress parameters, such as malondialdehyde (MDA) and total oxidant status (TOS), while it led to a decrease in antioxidant defense system parameters, such as reduced glutathione (GSH), superoxide dismutase (SOD), catalase (CAT) and total antioxidant status (TAS) when compared to control groups. Elevated MDA and TOS levels were observed, while reduced SOD and CAT activities, and decreased GSH and TAS levels were observed in the group that underwent PNX and ISO administration when compared to the PNX group. Furthermore, in the PNX + ISO + Crocin group, SOD and CAT activities, and GSH and TAS levels ameliorated and MDA and TOS levels were reduced with the crocin treatment when compared to the PNX + ISO group. Also, marked increases were observed in serum cardiac markers, histopathological and immunohistochemical findings after the crocin treatment. All findings demonstrated that crocin could be employed as a cardioprotective agent due to its antioxidant, anti-inflammatory, and anti-apoptotic properties.en_US
dc.description.sponsorshipKarabuk University Scientific Research Fund [TSA-2020-2282]en_US
dc.description.sponsorshipThe present study was sponsored by Karabuk University Scientific Research Fund (TSA-2020-2282).en_US
dc.identifier.doi10.1080/01480545.2021.1977025
dc.identifier.endpage2585en_US
dc.identifier.issn0148-0545
dc.identifier.issn1525-6014
dc.identifier.issue6en_US
dc.identifier.pmid34538161en_US
dc.identifier.scopus2-s2.0-85127425142en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage2576en_US
dc.identifier.urihttps://doi.org/10.1080/01480545.2021.1977025
dc.identifier.urihttps://hdl.handle.net/20.500.14619/5621
dc.identifier.volume45en_US
dc.identifier.wosWOS:000698250000001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofDrug and Chemical Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMyocardial infarctionen_US
dc.subjectpinealectomyen_US
dc.subjectcrocinen_US
dc.subjectmelatoninen_US
dc.subjectraten_US
dc.titleEffects of pinealectomy and crocin treatment on rats with isoproterenol-induced myocardial infarctionen_US
dc.typeArticleen_US

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