Onychomycosis is associated with subclinical atherosclerosis in patients with diabetes
Küçük Resim Yok
Tarih
2015
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Verlag Hans Huber Hogrefe Ag
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Background: We aimed to investigate the association of toenail onychomycosis with subclinical atherosclerosis in patients with diabetes mellitus. Patients and methods: Consecutive diabetic patients who were seen at our outpatient clinic were enrolled. The carotid intima-media thickness (CIMT) was assessed and toenail onychomycosis was diagnosed with microscopic evaluation. Results: We investigated 127 patients with diabetes melltus type 2. Overall, the prevalence of toenail onychomycosis was 37.8% (48 of 127). Of the 127 patients, 60 (47.2%) had subclinical atherosclerosis (CIMT >= 1 mm). Prevalence of male gender (43.3% vs. 22.4%, p = 0.012) and onychomycosis (53.3% vs. 23.9%, p = 0.001) was significantly higher in patients with subclinical atherosclerosis. Among biochemical parameters, low-density lipoprotein (122 +/- 38 mg/dL vs. 108 +/- 36 mg/dL, p = 0.039) and glycosylated hemoglobin levels (median 8.4%, IQR: 2.1% vs. median 7.5%, IQR: 1.6%, p = 0.002) were significantly higher in patients with subclinical atherosclerosis. Study groups were similar with respect to all other demographic, clinical, and laboratory parameters. After adjustment for all potential confounders, the presence of onychomycosis was independently associated with subclinical atherosclerosis (OR 2.77, 95 % CI 1.16 to 6.30) in multivariate logistic regression analysis. Conclusions: Presence of onychomycosis in patients with diabetes is associated with subclinical atherosclerosis. Onychomycosis may be a marker of atherosclerotic arterial involvement.
Açıklama
Anahtar Kelimeler
Onychomycosis, subclinical atherosclerosis, carotid intima-media thickness
Kaynak
Vasa-European Journal of Vascular Medicine
WoS Q Değeri
Q4
Scopus Q Değeri
Q2
Cilt
44
Sayı
1
