Microarray expression results of VEGF, YAP1 and PTEN immunostains in preeclampsia cases

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dc.contributor.authorAtigan, A.
dc.contributor.authorKarakaya, Y.A.
dc.contributor.authorKiliç, D.
dc.contributor.authorGuler, O.T.
dc.date.accessioned2024-09-29T16:21:03Z
dc.date.available2024-09-29T16:21:03Z
dc.date.issued2023
dc.departmentKarabük Üniversitesien_US
dc.description.abstractWe aimed to evaluate the expression of YAP1, PTEN, VEGF in the placentas of patients with preeclampsia and placentas of healthy pregnant women for trophoblast invasion, which is similar to cancer etiopathogenesis. The placentas of 70 women who gave birth, including 30 preeclampsia and 40 healthy controls, were evaluated. YAP1, PTEN and VEGF immunohistochemical staining were performed using the microarray method on placental tissue. The mean ± standard deviation for YAP1, PTEN and VEGF intensity were; 1.57 ± 0.71,2.59 ± 0.80, 1.61 ± 0.59, respectively. PTEN intensity was statistically significantly lower in the preeclampsia group than in the control group (2.37 ± 0.99 vs 2.75 ± 0.58, p = .049). There was no difference between the groups in terms of YAP1 and VEGF staining (p > .05). The etiopathogenesis of preeclampsia is still unclear. However, since trophoblast invasion and endothelial repair have similar aspects with cancer mechanisms, both preeclampsia and cancer studies are progressing by supporting each other. Our study is a prototype study showing that large-participation studies can be carried out easily by using the microarray method as an economic model. © 2023 Taylor & Francis.en_US
dc.identifier.doi10.1080/15321819.2023.2182219
dc.identifier.endpage212en_US
dc.identifier.issn1532-1819
dc.identifier.issue2en_US
dc.identifier.pmid36815553en_US
dc.identifier.scopus2-s2.0-85148585049en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage204en_US
dc.identifier.urihttps://doi.org/10.1080/15321819.2023.2182219
dc.identifier.urihttps://hdl.handle.net/20.500.14619/9513
dc.identifier.volume44en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor and Francis Ltd.en_US
dc.relation.ispartofJournal of Immunoassay and Immunochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectimmunohistochemistryen_US
dc.subjectmicroarrayen_US
dc.subjectpreeclampsiaen_US
dc.subjectPTENen_US
dc.subjectVEGFen_US
dc.subjectYAP1en_US
dc.titleMicroarray expression results of VEGF, YAP1 and PTEN immunostains in preeclampsia casesen_US
dc.typeArticleen_US

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