An investigation of the effectiveness of atmospheric pressure cold plasma on sciatic nerve injury in rats

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dc.authoridhttps://orcid.org/0000-0002-5527-8507
dc.authoridhttps://orcid.org/0000-0001-9254-175X
dc.authoridhttps://orcid.org/0000-0003-4448-5129
dc.authoridhttps://orcid.org/0000-0002-0118-6711
dc.authoridhttps://orcid.org/0000-0002-2669-021X
dc.contributor.authorYilmaz, Nesibe
dc.contributor.authorDeniz, Omur Gulsum
dc.contributor.authorSecgin, Seyda
dc.contributor.authorSecgin, Yusuf
dc.contributor.authorBozduman, Ferhat
dc.date.accessioned2025-03-04T07:09:53Z
dc.date.available2025-03-04T07:09:53Z
dc.date.issued2024-05-13
dc.departmentFakülteler, Tıp Fakültesi, Acil Tıp Bilimleri Bölümü
dc.description.abstractBackground: The aim of this study was to evaluate the efficacy of atmospheric pressure cold plasma jet and plasma activated medium (PAM) on sciatic nerve injury (SNI). Materials and methods: Rats were divided into 6 groups (n = 10); group 1 (sham), group 2 (SNI), group 3 (SNI + atmospheric pressure cold plasma jet 5 min), group 4 (SNI + atmospheric pressure cold plasma jet 10 min), group 5 (SNI + PAM 5 min), and group 6 (SNI + PAM 10 min). On days 1, 8, 15, and 22 of the study, atmospheric pressure cold plasma jet was applied to rats in groups 3 and 4, and PAM was applied to rats in groups 5 and 6. A hot plate test was applied to all rats on the same days. On day 28, the experiment was terminated, and sciatic nerve tissues were removed for histopathological evaluation. Results: According to the 4-week average of the hot plate tests, a significant relationship was found between group 2 and group 4 and group 6 (p < 0.05). When evaluated within each week, significant differences were found between group 2 and group 4 in week 1, between group 2 and group 5 and group 6 in week 2, between group 2 and group 4 in week 3, and between group 2 and group 4 and group 6 in week 4 (p < 0.05). As a result of histopathological analysis, except for the control group, the other groups had similar characteristics in terms of axonal degeneration, periaxonal swelling, and axon density. Conclusions: As a result of our study, we found that plasma application showed an improvement in the duration of the hot plate test but did not show any improvement histopathologically.
dc.identifier10.5603/fm.100019
dc.identifier.citationYılmaz, N., Deniz, O. G., Secgin, S., Secgin, Y., & Bozduman, F. (2024). An investigation of the effectiveness of atmospheric pressure cold plasma on sciatic nerve injury in rats. Folia morphologica, 83(4), 813–822. https://doi.org/10.5603/fm.100019
dc.identifier.doi10.5603/fm.100019
dc.identifier.endpage822
dc.identifier.issn0015-5659
dc.identifier.issue4
dc.identifier.pmid38757499
dc.identifier.scopus2-s2.0-85213831480
dc.identifier.scopusqualityQ2
dc.identifier.startpage813
dc.identifier.urihttps://doi.org/10.5603/fm.100019
dc.identifier.urihttps://hdl.handle.net/20.500.14619/15109
dc.identifier.volume83
dc.indekslendigikaynakPubMed
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherVia Medica
dc.relation.ispartofFolia Morphologica (Poland)
dc.relation.ispartofseriesFolia Morphologica (Poland)
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectatmospheric pressure cold plasma jet
dc.subjecthistopathology
dc.subjecthot plate test
dc.subjectplasma-activated media
dc.subjectsciatic injury
dc.titleAn investigation of the effectiveness of atmospheric pressure cold plasma on sciatic nerve injury in rats
dc.typeArticle
oaire.citation.issue4
oaire.citation.volume83

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