Molecular Genetic Influences on Normative and Problematic Alcohol Use in a Population-Based Sample of College Students

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dc.authoridSavage, Jeanne/0000-0002-2034-8341
dc.authoridHickman, Matthew/0000-0001-9864-459X
dc.authoridWebb, Bradley/0000-0002-0576-5366
dc.authoridNeale, Zoe/0000-0001-6440-2445
dc.authoridEdwards, Alexis/0000-0002-4006-9710
dc.authoridCho, Seung Bin/0000-0003-0336-6625
dc.authoridWolen, Aaron/0000-0003-2542-2202
dc.contributor.authorWebb, Bradley T.
dc.contributor.authorEdwards, Alexis C.
dc.contributor.authorWolen, Aaron R.
dc.contributor.authorSalvatore, Jessica E.
dc.contributor.authorAliev, Fazil
dc.contributor.authorRiley, Brien P.
dc.contributor.authorSun, Cuie
dc.date.accessioned2024-09-29T16:08:01Z
dc.date.available2024-09-29T16:08:01Z
dc.date.issued2017
dc.departmentKarabük Üniversitesien_US
dc.description.abstractBackground : Genetic factors impact alcohol use behaviors and these factors may become increasingly evident during emerging adulthood. Examination of the effects of individual variants as well as aggregate genetic variation can clarify mechanisms underlying risk. Methods : We conducted genome-wide association studies (GWAS) in an ethnically diverse sample of college students for three quantitative outcomes including typical monthly alcohol consumption, alcohol problems, and maximum number of drinks in 24 h. Heritability based on common genetic variants (h(SNP)(2)) was assessed. We also evaluated whether risk variants in aggregate were associated with alcohol use outcomes in an independent sample of young adults. Results : Two genome-wide significant markers were observed: rs11201929 in GRID1 for maximum drinks in 24 h, with supportive evidence across all ancestry groups; and rs73317305 in SAMD12 (alcohol problems), tested only in the African ancestry group. The h(SNP)(2) estimate was 0.19 (SE = 0.11) for consumption, and was non-significant for other outcomes. Genome-wide polygenic scores were significantly associated with alcohol outcomes in an independent sample. Conclusions : These results robustly identify genetic risk for alcohol use outcomes at the variant level and in aggregate. We confirm prior evidence that genetic variation in GRID1 impacts alcohol use, and identify novel loci of interest for multiple alcohol outcomes in emerging adults. These findings indicate that genetic variation influencing normative and problematic alcohol use is, to some extent, convergent across ancestry groups. Studying college populations represents a promising avenue by which to obtain large, diverse samples for gene identification.en_US
dc.description.sponsorshipNational Institute on Alcohol Abuse and Alcoholism [P20AA017828, R37AA011408, K02AA018755, P50AA022537]; National Center for Advancing Translational Studies [UL1TR000058]; National Center for Research Resources [UL1RR031990]; National Institutes of Health Roadmap for Medical Research [R01AA018333, K01AA021399, K01AA024152, F31AA024380]; UK Medical Research Council; Wellcome Trust [102215/2/13/2]; University of Bristol provide; ALSPAC; MRC [MR/L022206/1]; ESRC [ES/L015471/1]; ESRC [ES/L015471/1] Funding Source: UKRI; MRC [MR/L022206/1] Funding Source: UKRIen_US
dc.description.sponsorshipThe Spit for Science project is supported by P20AA017828, R37AA011408, K02AA018755, and P50AA022537 from the National Institute on Alcohol Abuse and Alcoholism; UL1TR000058, from the National Center for Advancing Translational Studies; and UL1RR031990 from the National Center for Research Resources and National Institutes of Health Roadmap for Medical Research, with additional support for this research through R01AA018333 (DD/KK); K01AA021399 (AE); K01AA024152 (JESalvatore); and F31AA024380 (MC). We would like to thank the Virginia Commonwealth University students for making this study a success, as well as the many VCU faculty, students, and staff who contributed to the design and implementation of the project. With respect to the ALSPAC data, we are extremely grateful to all the families who took part in this study, the midwives for their help in recruiting them, and the whole ALSPAC team, which includes interviewers, computer and laboratory technicians, clerical workers, research scientists, volunteers, managers, receptionists and nurses. The UK Medical Research Council and the Wellcome Trust (Grant ref: 102215/2/13/2) and the University of Bristol provide core support for ALSPAC. This publication is the work of the authors and BW will serve as guarantor for the contents of this paper. This research was additionally specifically funded by support from MRC and ESRC (MR/L022206/1 and ES/L015471/1).en_US
dc.identifier.doi10.3389/fgene.2017.00030
dc.identifier.issn1664-8021
dc.identifier.pmid28360924en_US
dc.identifier.scopus2-s2.0-85017154834en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.3389/fgene.2017.00030
dc.identifier.urihttps://hdl.handle.net/20.500.14619/7315
dc.identifier.volume8en_US
dc.identifier.wosWOS:000402720200001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherFrontiers Media Saen_US
dc.relation.ispartofFrontiers in Geneticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectalcohol problemsen_US
dc.subjectalcohol consumptionen_US
dc.subjectGWASen_US
dc.subjectheritabilityen_US
dc.subjectgenetic ancestryen_US
dc.subjectgenome-wide polygenic scoreen_US
dc.titleMolecular Genetic Influences on Normative and Problematic Alcohol Use in a Population-Based Sample of College Studentsen_US
dc.typeArticleen_US

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