Pinealectomy and melatonin administration in rats: their effects on pulmonary edema induced by ?-naphthylthiourea

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dc.authoridYilmaz, Umit/0000-0003-0248-3483
dc.authoridyilmaz, nesibe/0000-0002-5527-8507
dc.authoridDEMIR, MEHMET/0000-0001-6990-3337
dc.authoridAltinoz, Eyup/0000-0002-3991-9773
dc.authoridOzgul Onal, Melike/0000-0001-6710-5729
dc.contributor.authorAl Gburi, Mohammed Raed Abdullah
dc.contributor.authorAltinoz, Eyup
dc.contributor.authorElbe, Hulya
dc.contributor.authorOnal, Melike Ozgul
dc.contributor.authorYilmaz, Umit
dc.contributor.authorYilmaz, Nesibe
dc.contributor.authorKarayakali, Melike
dc.date.accessioned2024-09-29T16:01:16Z
dc.date.available2024-09-29T16:01:16Z
dc.date.issued2023
dc.departmentKarabük Üniversitesien_US
dc.description.abstractWe aimed to observe the possible effects of melatonin (MLT) deprivation (pinealectomy) and exogenous MLT administration on pulmonary edema induced by alpha-naphthylthiourea (ANTU), a toxic chemical agent, in rats. Seventy animals were assigned to seven groups: control, sham pinealectomy (PINX), PINX, ANTU (10 mg/kg intraperitoneal on day 30), ANTU + MLT (10 mg/kg/day i.p. for 30 days), ANTU + PINX, and ANTU + PINX + MLT. In this study, pleural effusion (PE) formation, lung weight/body weight (LW/BW) and PE/BW ratios (fluid accumulation and weight values in the lungs) increase detected. Pre-ANTU MLT administration led to significant decreases in PE, LW/BW, and PE/BW levels. The inhibited glutathione (GSH) and superoxide dismutase (SOD) levels and high malondialdehyde (MDA) levels that ANTU increase lipid peroxidation in the study. MLT administration eliminated oxidative stress by reducing MDA and ameliorating GSH and SOD levels. Pre-ANTU MLT administration led to a significant decrease in interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha) levels in the lung when compared to the ANTU group without MLT administration. Post-pinealectomy ANTU administration significantly increased IL-1 beta and TNF-alpha levels when compared to ANTU and MLT administration without pinealectomy. Diffused inflammatory cell infiltration, interstitial pulmonary edema, and histopathological congestion were observed after the administration of ANTU. Severity of the damage was elevated in the ANTU + PINX group. MLT treatment regressed pulmonary effusion and edema and improves lung structure. In brief, the findings suggested that MLT inhibited proinflammatory mediators and could serve as a therapeutic agent to prevent inflammatory disorders.en_US
dc.description.sponsorshipKarabuk University Scientific Research Fund [KBUBAP-21-YL-043]en_US
dc.description.sponsorshipThe research was supported by Karabuk University Scientific Research Fund [KBUBAP-21-YL-043].en_US
dc.identifier.doi10.1080/01480545.2022.2119994
dc.identifier.endpage1034en_US
dc.identifier.issn0148-0545
dc.identifier.issn1525-6014
dc.identifier.issue5en_US
dc.identifier.pmid36069203en_US
dc.identifier.scopus2-s2.0-85137754965en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1024en_US
dc.identifier.urihttps://doi.org/10.1080/01480545.2022.2119994
dc.identifier.urihttps://hdl.handle.net/20.500.14619/5622
dc.identifier.volume46en_US
dc.identifier.wosWOS:000850913900001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofDrug and Chemical Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAlpha-naphthylthioureaen_US
dc.subjectmelatoninen_US
dc.subjectoxidative stressen_US
dc.subjectpinealectomyen_US
dc.subjectpulmonary edemaen_US
dc.subjectraten_US
dc.titlePinealectomy and melatonin administration in rats: their effects on pulmonary edema induced by ?-naphthylthioureaen_US
dc.typeArticleen_US

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