Dose-dependent effects of kefir on colitis induced by trinitrobenzene sulfonic acid in rats

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dc.authoridKapucuoglu, Fatma Nilgun/0000-0002-0016-6479
dc.authoridOZKAN SEVENCAN, NURHAYAT/0000-0001-9013-3517
dc.contributor.authorSevencan, Nurhayat Ozkan
dc.contributor.authorIsler, Mehmet
dc.contributor.authorKapucuoglu, Fatma Nilgun
dc.contributor.authorSenol, Altug
dc.contributor.authorKayhan, Burcak
dc.contributor.authorKiztanir, Sefa
dc.contributor.authorKockar, Muhammed Cem
dc.date.accessioned2024-09-29T15:50:41Z
dc.date.available2024-09-29T15:50:41Z
dc.date.issued2019
dc.departmentKarabük Üniversitesien_US
dc.description.abstractEvidence suggests that gut microbiota dysbiosis plays a critical role in the initiation and promotion of inflammatory bowel disease (IBD). Kefir is a fermented dairy product including yeast and bacterial species. We aimed to investigate the effect of kefir on trinitrobenzene sulfonic acid (TNBS)-induced colitis in rats using two different doses. Fifty-four Wistar rats were divided into six groups. For 14 days, the normal control and colitis control groups were given tap water, kefir10 control, kefir10 colitis, and kefir30 control, and the kefir30 colitis groups were given phosphate-buffered saline containing 10% or 30% kefir, respectively, instead of tap water. Colitis was induced by intracolonically administrating TNBS in the colitis control, kefir10 colitis, and kefir30 colitis groups. On the 14th day, the rats were sacrificed. The weights and lengths of the colons were measured and macroscopically evaluated, and the distal 10 cm segments were subjected to a histopathological examination. The incidence of bloody stool and diarrhea in the kefir10 colitis group was found to be less than the colitis control and kefir30 colitis groups. The colonic weight/length ratio in the kefir10 colitis group was lower than that in the colitis control and kefir30 colitis groups. We detected that the 10% kefir treatment reduced TNBS-induced macroscopic colonic damage, while it was exacerbated by the 30% kefir treatment. No significant difference was observed between the colitis groups in terms of microscopic colonic damage scoring. These results indicate that kefir, with a careful dose selection, may be a useful agent in the treatment of IBD.en_US
dc.description.sponsorshipSuleyman Demirel University Research Projects Management Unit [1303-TU-06]en_US
dc.description.sponsorshipThe study was supported by Suleyman Demirel University Research Projects Management Unit (Project No: 1303-TU-06).en_US
dc.identifier.doi10.1002/fsn3.1174
dc.identifier.endpage3118en_US
dc.identifier.issn2048-7177
dc.identifier.issue9en_US
dc.identifier.pmid31572604en_US
dc.identifier.scopus2-s2.0-85070878658en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage3110en_US
dc.identifier.urihttps://doi.org/10.1002/fsn3.1174
dc.identifier.urihttps://hdl.handle.net/20.500.14619/3686
dc.identifier.volume7en_US
dc.identifier.wosWOS:000482821100001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofFood Science & Nutritionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectcolitisen_US
dc.subjectinflammatory bowel diseaseen_US
dc.subjectkefiren_US
dc.subjectprobioticen_US
dc.subjecttrinitrobenzene sulfonic aciden_US
dc.titleDose-dependent effects of kefir on colitis induced by trinitrobenzene sulfonic acid in ratsen_US
dc.typeArticleen_US

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