Therapeutic role of melatonin on acrylamide-induced hepatotoxicity in pinealectomized rats: Effects on oxidative stress, NF-KB signaling pathway, and hepatocellular proliferation

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dc.authoridAltinoz, Eyup/0000-0002-3991-9773
dc.contributor.authorOzturk, Ipek
dc.contributor.authorElbe, Hulya
dc.contributor.authorBicer, Yasemin
dc.contributor.authorKarayakali, Melike
dc.contributor.authorOnal, Melike Ozgul
dc.contributor.authorAltinoz, Eyup
dc.date.accessioned2024-09-29T15:57:10Z
dc.date.available2024-09-29T15:57:10Z
dc.date.issued2023
dc.departmentKarabük Üniversitesien_US
dc.description.abstractAcrylamide (AA) is formed in some foods by the cooking process at high temperatures, and it could be a carcinogen in humans and rodents. The purpose of the current study was to reveal the possible protective effects of melatonin against AA-induced hepatic oxidative stress, hepatic inflammation, and hepatocellular proliferation in pinealectomized rats. Hence, the sham and pinealectomized rats were consecutively given AA alone (25 mg/ kg) or with melatonin (10 mg/kg) for 21 days. Melatonin acts as an antioxidant, anti-inflammatory, and anti-apoptotic agent and introduces as a therapeutic strategy for AA-induced hepatotoxicity. Melatonin supplemen-tation reduced AA-caused liver damage by decreasing the serum AST, ALT, and ALP levels. Melatonin raised the activities of SOD and CAT and levels of GSH and suppressed hepatic inflammation (TNF-alpha) and hepatic oxidative stress in liver tissues. Moreover, histopathological alterations and the disturbances in immunohistochemical expression of NF-KB and Ki67 were improved after melatonin treatment in AA-induced hepatotoxicity. Overall, our results demonstrate that melatonin supplementation exhibits adequate hepatoprotective effects against hepatotoxicity of AA on pinealectomized rat liver architecture and the tissue function through the equilibration of oxidant/antioxidant status, the regulation of cell proliferation and the suppression of the release of proin-flammatory cytokines.en_US
dc.description.sponsorshipKarabuk University, Department of Scientific Researches Projects [KBUBAP-21-YL-117]en_US
dc.description.sponsorshipThis study was sponsored by Karabuk University, Department of Scientific Researches Projects (Project number: KBUBAP-21-YL-117) .en_US
dc.identifier.doi10.1016/j.fct.2023.113658
dc.identifier.issn0278-6915
dc.identifier.issn1873-6351
dc.identifier.pmid36780936en_US
dc.identifier.scopus2-s2.0-85148099546en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1016/j.fct.2023.113658
dc.identifier.urihttps://hdl.handle.net/20.500.14619/4647
dc.identifier.volume174en_US
dc.identifier.wosWOS:000939562700001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofFood and Chemical Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcrylamideen_US
dc.subjectMelatoninen_US
dc.subjectHepatotoxicityen_US
dc.subjectKi67en_US
dc.subjectNF-KBen_US
dc.subjectPinealectomyen_US
dc.titleTherapeutic role of melatonin on acrylamide-induced hepatotoxicity in pinealectomized rats: Effects on oxidative stress, NF-KB signaling pathway, and hepatocellular proliferationen_US
dc.typeArticleen_US

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