Synthesis, Aggregation, Antioxidant and DNA-Binding Properties of Metallophthalocyanines Bearing 5-Tert-butyl-2-hydroxyphenoxy Groups

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dc.authoridOkumus, Veysi/0000-0002-5505-2700
dc.contributor.authorAgirtas, Mehmet Salih
dc.contributor.authorCabir, Beyza
dc.contributor.authorOzdemir, Sadin
dc.contributor.authorOkumus, Veysi
dc.contributor.authorArslantas, Ali
dc.date.accessioned2024-09-29T15:50:50Z
dc.date.available2024-09-29T15:50:50Z
dc.date.issued2017
dc.departmentKarabük Üniversitesien_US
dc.description.abstractIn this study, the synthesis and characterization of new substituted metallophthalocyanines are described. A new phthalonitrile, 4-(5-tert-butyl-2-hydroxyphenoxy)-5-chlorophthalonitrile (3) was prepared. New compounds were characterized by UV-Vis, IR, H-1 NMR, and elemental analysis. The aggregation behavior of the cobalt (II), magnesium (II) and copper (II) phthalocyanines were studied in tetrahydrofuran and in known concentration ranges. The antioxidant activities of compounds were evaluated. Their radical-scavenging capacity, metal chelating activity and reducing power was fully studied. The compound 3 showed 100% chelating activity as EDTA at concentration 50 mg/L. The DNA interaction of copper (II) phthalocyanine compound (6) was studied using UV/Vis titration, gel electrophoresis, cyclic voltammetry. The results indicated that compound 6 interacts with CT-DNA via intercalation binding mode.en_US
dc.identifier.doi10.1002/slct.201702461
dc.identifier.endpage11357en_US
dc.identifier.issn2365-6549
dc.identifier.issue34en_US
dc.identifier.scopus2-s2.0-85041863526en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage11352en_US
dc.identifier.urihttps://doi.org/10.1002/slct.201702461
dc.identifier.urihttps://hdl.handle.net/20.500.14619/3745
dc.identifier.volume2en_US
dc.identifier.wosWOS:000417743100059en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherWiley-V C H Verlag Gmbhen_US
dc.relation.ispartofChemistryselecten_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAggregationen_US
dc.subjectAntioxidanten_US
dc.subjectDNA Bindingen_US
dc.subjectPhthalocyaninesen_US
dc.subjectSynthesisen_US
dc.titleSynthesis, Aggregation, Antioxidant and DNA-Binding Properties of Metallophthalocyanines Bearing 5-Tert-butyl-2-hydroxyphenoxy Groupsen_US
dc.typeArticleen_US

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