In vitro antioxidant activity and carbonic anhydrase inhibitory features of ferula communis extracts

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dc.contributor.authorAydın, Fatma Gülruy
dc.contributor.authorKahraman, Zeynep Aleyna
dc.contributor.authorTürkoğlu, Emir Alper
dc.contributor.authorKuzu, Müslüm
dc.contributor.authorSeveroğlu, Zeki
dc.date.accessioned2024-09-29T16:30:47Z
dc.date.available2024-09-29T16:30:47Z
dc.date.issued2021
dc.departmentKarabük Üniversitesien_US
dc.description.abstractCarbonic anhydrases (CAs; EC 4.2.1.1) are essential family of metalloenzymes which catalyze the interconversion between carbon dioxide (CO2) and bicarbonate (HCO3-) in all organisms of three-domains of life. Huge amounts of attempts related to catalytic activity of CAs have been widely expanded to treat many clinical diseases. This study aimed to determine in-vitro antioxidant activities and human CA I (hCA I) and II (hCA II) inhibitory properties of Ferula communis extracts. Among all extracts of F. communis, the hexane extract has showed the best inhibitory profile on hCA I and II with IC50 values 8.68 µg/mL and 28 µg/mL and Ki values 2.026 µg/mL and 11.6 µg/mL, respectively. All extracts showed mild to moderate antioxidant activity. According to the results of DPPH assay, ethanol-water extract showed the highest activity with IC50: 0.1128±0.0066 value. Chloroform extract showed the highest activity on CUPRAC assay with the value of 1.305±0.037 mM Trolox equivalent/mg extract. However, further analytical, in-vivo and clinical studies are needed to confirm the activities of F. communis.en_US
dc.identifier.doi10.31015/jaefs.2021.4.19
dc.identifier.endpage598en_US
dc.identifier.issn2602-246X
dc.identifier.issue4en_US
dc.identifier.startpage592en_US
dc.identifier.trdizinid1229633en_US
dc.identifier.urihttps://doi.org/10.31015/jaefs.2021.4.19
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1229633
dc.identifier.urihttps://hdl.handle.net/20.500.14619/10904
dc.identifier.volume5en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofInternational Journal of Agriculture, Environment and Food Sciencesen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleIn vitro antioxidant activity and carbonic anhydrase inhibitory features of ferula communis extractsen_US
dc.typeArticleen_US

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