OPTIMIZATION OF ETHANOL SUPERCRITICAL FLUID EXTRACTION OF MEDICINAL COMPOUNDS FROM ST. JOHN'S WORT BY CENTRAL COMPOSITE DESIGN

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dc.contributor.authorAkalin, Mehmet Kuddusi
dc.contributor.authorKaragoz, Selhan
dc.date.accessioned2024-09-29T16:01:11Z
dc.date.available2024-09-29T16:01:11Z
dc.date.issued2014
dc.departmentKarabük Üniversitesien_US
dc.description.abstractExtraction of medicinal compounds from St John's Wort was performed using supercritical ethanol. The supercritical fluid extraction parameters were optimized via response surface methodology which included a central composite design. The independent variables were extraction temperature (ranging from 300 degrees C to 340 degrees C), extraction times (ranging from 60 to 120 min), and plant concentration (ranging from 8% to 12%). The response was the St John's Wort extract yield. The extraction temperature was the most significant factor which affects St John's Wort yields according to statistical results. The coefficient of determination was estimated to be 0.98 which indicates the effectiveness of the model and its adaptability to the experimental data. The extract of St John's Wort was comprised of a wide array of compounds including phenols, acids, acid esters, and alkanes. The most prominent components of the extract of St. John's Wort in terms of their relative concentrations were linoleic acid ethyl ester, oleic acid ethyl ester, hexadecanoic acid ethyl ester, and nonacosane.en_US
dc.description.sponsorshipKarabuk University [KBU-BAP-13/1-DR-008]en_US
dc.description.sponsorshipThe financial support under the contract (KBU-BAP-13/1-DR-008) from the Karabuk University is gratefully acknowledged.en_US
dc.identifier.doi10.1080/00032719.2014.888724
dc.identifier.endpage1911en_US
dc.identifier.issn0003-2719
dc.identifier.issn1532-236X
dc.identifier.issue11en_US
dc.identifier.scopus2-s2.0-84903384900en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1900en_US
dc.identifier.urihttps://doi.org/10.1080/00032719.2014.888724
dc.identifier.urihttps://hdl.handle.net/20.500.14619/5582
dc.identifier.volume47en_US
dc.identifier.wosWOS:000338718100009en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofAnalytical Lettersen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCentral composite designen_US
dc.subjectResponse surface methodologyen_US
dc.subjectSt John's Worten_US
dc.titleOPTIMIZATION OF ETHANOL SUPERCRITICAL FLUID EXTRACTION OF MEDICINAL COMPOUNDS FROM ST. JOHN'S WORT BY CENTRAL COMPOSITE DESIGNen_US
dc.typeArticleen_US

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