Synthesis and Characterization of Oxime Derivatives and their Some Transition Metal Complexes with Thiadiazole Groups: Biological Activities, and Molecular Docking Studies of the Ligands
Küçük Resim Yok
Tarih
2024
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Wiley-V C H Verlag Gmbh
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
This study involved the synthesis and investigation of the anticancer and antioxidant capabilities of six newly developed ligands generated from 1,3,4-thiadiazole and diphenyl ether keto oxime which has never been synthesized before, together with their transition metal complexes. The obtained ligands were characterized using elemental analysis, FTIR, 1H NMR, 13C NMR, and mass spectroscopy. Polymeric complexes of the obtained ligands were synthesized by reacting all ligands with MCl2.nH2O (M: Mn2+/Co2+)/Ni2+/Cu2+)) salts. The polymeric complexes ' structures were determined using elemental analysis, ICP-AES, FTIR spectroscopy, UV-vis spectroscopy, magnetic susceptibility analysis, and thermogravimetric analysis. Subsequently, the ligands were examined for their anticancer properties. To achieve this objective, the HT-22 cell line, which consists of healthy mouse hippocampus neuronal cells, is utilized as the control group. Additionally, the MCF7 (breast cancer), MDA-MB-231 (breast cancer), C6 (rat glioma), HT-29 (colon cancer), and A549 (lung carcinoma) cell lines are employed in cell culture research as representatives of cancerous cell lines. Based on the cell culture investigations, some of the synthesized ligands showed moderate to good anti-cancer activity, especially for both colon cancer and brain tumors. Finally, a molecular docking analysis was conducted utilizing MOE software to ascertain the binding affinity between the synthesized ligands and the specific proteins of interest. This study includes the synthesis of transition metal complexes of six new ligands obtained from 1,3,4-thiadiazole and diphenyl ether keto oxime and the investigation of the anticancer and antioxidant properties of the ligands. Finally, a molecular docking analysis was performed to determine the binding affinity between the synthesized ligands and specific proteins of interest. image
Açıklama
Anahtar Kelimeler
Oxime, 1,3,4-Thiadiazole, Transition Metal Complex, Anticancer activity, Antioxidant activity
Kaynak
Chemistryselect
WoS Q Değeri
N/A
Scopus Q Değeri
Q2
Cilt
9
Sayı
16
