SYNTHESIS AND CHARACTERIZATION OF NOVEL 1,3-THIAZOLE AND 2-AMINO-1,3,4-THIADIAZOLE DERIVATIVES

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dc.authoridTAHTACI, HAKAN/0000-0002-1557-6315
dc.contributor.authorEr, Mustafa
dc.contributor.authorSahin, Ayse
dc.contributor.authorTahtaci, Hakan
dc.date.accessioned2024-09-29T16:06:39Z
dc.date.available2024-09-29T16:06:39Z
dc.date.issued2014
dc.departmentKarabük Üniversitesien_US
dc.description.abstractThiosemicarbazone derivatives 3a-e were synthesized by the reaction of various aldehydes 1a-e with 4-methyl thiosemicarbazide 2 in 78% to 90% yield. Then, the thiazole moieties of the target materials 5a-e were obtained in high yields (71-93%) using the Hantzsch reaction utilizing thiosemicarbazone derivatives 3a-e with ethyl-2-chloroacetoacetic ester. The substituted nitrile derivatives 7a-e were obtained in moderate to high yield (58-84%) from the reaction of compounds 5a-e with chloroacetonitrile by the nucleophilic aliphatic substitution reaction in the presence of anhydrous potassium carbonate. Finally, substituted 2-amino-1,3,4-thiadiazole compounds 9a-e were obtained in moderate to good yields (51-62%) from the reaction of thiosemicarbazide with substituted nitrile derivatives 7a-e. As a result, compounds that all share a high disposition for biological activities were obtained. The structures of the newly synthesized compounds were confirmed by IR, H-1 NMR, C-13 NMR, elemental analysis, and mass spectrometric techniques.en_US
dc.identifier.doi10.20450/mjcce.2014.522
dc.identifier.endpage198en_US
dc.identifier.issn1857-5552
dc.identifier.issn1857-5625
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-84929327126en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage189en_US
dc.identifier.urihttps://doi.org/10.20450/mjcce.2014.522
dc.identifier.urihttps://hdl.handle.net/20.500.14619/6969
dc.identifier.volume33en_US
dc.identifier.wosWOS:000356592500001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSoc Chemists Technologists Madeconiaen_US
dc.relation.ispartofMacedonian Journal of Chemistry and Chemical Engineeringen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectthiosemicarbazoneen_US
dc.subject1,3-thiazoleen_US
dc.subject2-amino-1,3,4-thiadiazoleen_US
dc.subjectHantzsch reactionen_US
dc.titleSYNTHESIS AND CHARACTERIZATION OF NOVEL 1,3-THIAZOLE AND 2-AMINO-1,3,4-THIADIAZOLE DERIVATIVESen_US
dc.typeArticleen_US

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