Cerebrospinal Fluid Dynamics in Patients with Multiple Sclerosis: The Role of Phase-Contrast MRI in the Differential Diagnosis of Active and Chronic Disease

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dc.authoridMaras Ozdemir, Zeynep/0000-0003-1085-8978
dc.authoridKahraman, Aysegul Sagir/0000-0002-2147-1181
dc.authoridOner, Serkan/0000-0002-7802-880X
dc.authoridozcan, abdulcemal/0000-0002-6759-7556
dc.authoridKamisli, Ozden/0000-0003-1114-7860
dc.authoridunlu, serkan/0000-0001-7535-0812
dc.contributor.authorOner, Serkan
dc.contributor.authorKahraman, Aysegul Sagir
dc.contributor.authorOzcan, Cemal
dc.contributor.authorOzdemir, Zeynep Maras
dc.contributor.authorUnlu, Serkan
dc.contributor.authorKamisli, Ozden
dc.contributor.authorOner, Zulal
dc.date.accessioned2024-09-29T16:07:59Z
dc.date.available2024-09-29T16:07:59Z
dc.date.issued2018
dc.departmentKarabük Üniversitesien_US
dc.description.abstractObjective: Multiple sclerosis (MS) is an inflammatory disease characterized by demyelinating plaques in the white matter. Chronic cerebrospinal venous insufficiency (CCSVI) has been proposed as a new hypothesis for the etiopathogenesis of MS disease. MS-CCSVI includes a significant decrease of cerebrospinal fluid (CSF) flow through the cerebral aqueduct secondary to an impaired venous outflow from the central nervous system. This study aimed to determine whether CSF flow dynamics are affected in MS patients and the contributions to differential diagnosis in active and chronic disease using phase-contrast magnetic resonance imaging (PC-MRI). Materials and Methods: We studied 16 MS patients with chronic plaques (group 1), 16 MS patients with active plaques-enhanced on MRI (group 2), and 16 healthy controls (group 3). Quantitatively evaluation of the CSF flow was performed from the level of the cerebral aqueduct by PC-MRI. According to heart rates, 14-30 images were obtained in a cardiac cycle. Cardiac triggering was performed prospectively using finger plethysmography. Results: No statistically significant difference was found between the groups regarding average velocity, net forward volume and the average flow (p > 0.05). Compared with the controls, group 1 and group 2, showed a higher peak velocity (5.5 +/- 1.4, 4.9 +/- 1.0, and 4.3 +/- 1.3 cm/sec, respectively; p = 0.040), aqueductal area (5.0 +/- 1.3, 4.1 +/- 1.5, and 3.1 +/- 1.2 mm(2), respectively; p = 0.002), forward volume (0.039 +/- 0.016, 0.031 +/- 0.013, and 0.021 +/- 0.010 mL, respectively; p = 0.002) and reverse volume (0.027 +/- 0.016, 0.018 +/- 0.009, and 0.012 +/- 0.006 mL, respectively; p = 0.000). There were no statistical significance between the MS patients with chronic plaques and active plaques except for reverse volume. The MS patients with chronic plaques showed a significantly higher reverse volume (p = 0.000). Conclusion: This study indicated that CSF flow is affected in MS patients, contrary to the hypothesis that CCSVI-induced CSF flow decreases in MS patients. These findings may be explained by atrophy-dependent ventricular dilatation, which may occur at every stage of MS.en_US
dc.identifier.doi10.3348/kjr.2018.19.1.72
dc.identifier.endpage78en_US
dc.identifier.issn1229-6929
dc.identifier.issn2005-8330
dc.identifier.issue1en_US
dc.identifier.pmid29354002en_US
dc.identifier.scopus2-s2.0-85040769804en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage72en_US
dc.identifier.urihttps://doi.org/10.3348/kjr.2018.19.1.72
dc.identifier.urihttps://hdl.handle.net/20.500.14619/7302
dc.identifier.volume19en_US
dc.identifier.wosWOS:000426981400009en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKorean Radiological Socen_US
dc.relation.ispartofKorean Journal of Radiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCerebrospinal fluid dynamicsen_US
dc.subjectMultiple sclerosisen_US
dc.subjectChronic cerebrospinal venous insufficiencyen_US
dc.subjectPhase contrast cine MRIen_US
dc.titleCerebrospinal Fluid Dynamics in Patients with Multiple Sclerosis: The Role of Phase-Contrast MRI in the Differential Diagnosis of Active and Chronic Diseaseen_US
dc.typeArticleen_US

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