The effects of acrylamide and vitamin E on kidneys in pregnancy: an experimental study

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dc.authoridAltinoz, Eyup/0000-0002-3991-9773
dc.authoridTurkoz, Yusuf/0000-0001-5401-0720
dc.authoridYigitcan, Birgul/0000-0002-7910-4595
dc.authoridGozukara Bag, Harika Gozde/0000-0003-1208-4072
dc.contributor.authorErdemli, Mehmet Erman
dc.contributor.authorAksungur, Zeynep
dc.contributor.authorGul, Mehmet
dc.contributor.authorYigitcan, Birgul
dc.contributor.authorBag, Harika Gozukara
dc.contributor.authorAltinoz, Eyup
dc.contributor.authorTurkoz, Yusuf
dc.date.accessioned2024-09-29T16:02:53Z
dc.date.available2024-09-29T16:02:53Z
dc.date.issued2019
dc.departmentKarabük Üniversitesien_US
dc.description.abstractObjectives: The objective of this study is to investigate possible damages to kidney tissues of pregnant rats and their fetuses exposed to acrylamide during pregnancy and possible protective effects of vitamin E against these damages. Material and methods: Rats were randomly assigned to five groups of control, corn oil, vitamin E, acrylamide, vitamin E + acrylamide, six pregnant rats in each. Mother and fetal kidney tissues were examined for malondialdehyde (MDA), reductase glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), total antioxidant status (TAS), total oxidant status (TOS), urea, creatine, trace elements such as Zn and Cu in the serum and histopathological analyses were conducted. Results: It was determined that acrylamide, administered during pregnancy, statistically significantly increased MDA and TOS levels, maternal serum urea, creatinine, and Zn levels, while it decreased GSH, TAS, SOD, and CAT levels (p <= .05) when compared with all other groups in the kidney tissues of pregnant rats and their fetuses and caused tubular degeneration, hemorrhage, narrowing, and closure in Bowman's space, and, in the E vitamin group, it statistically significantly increased GSH, TAS, SOD, CAT, urea, creatinine, and Zn levels when compared with other groups and lowered TOS and MDA levels to those of the control group (p < .05) and there were no differences between the groups histologically. Conclusion: It was observed that acrylamide administered during pregnancy caused oxidative stress in kidney tissues of mother rats and their fetuses, resulting in tissue damage, and vitamin E application, which is considered to be a powerful antioxidant, inhibited oxidative stress.en_US
dc.identifier.doi10.1080/14767058.2018.1471675
dc.identifier.endpage3756en_US
dc.identifier.issn1476-7058
dc.identifier.issn1476-4954
dc.identifier.issue22en_US
dc.identifier.pmid29764249en_US
dc.identifier.scopus2-s2.0-85047161377en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage3747en_US
dc.identifier.urihttps://doi.org/10.1080/14767058.2018.1471675
dc.identifier.urihttps://hdl.handle.net/20.500.14619/5772
dc.identifier.volume32en_US
dc.identifier.wosWOS:000478603200008en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofJournal of Maternal-Fetal & Neonatal Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcrylamideen_US
dc.subjectfetusen_US
dc.subjectkidneysen_US
dc.subjectmotheren_US
dc.subjectoxidative stressen_US
dc.subjectpregnancyen_US
dc.subjectvitamin Een_US
dc.titleThe effects of acrylamide and vitamin E on kidneys in pregnancy: an experimental studyen_US
dc.typeArticleen_US

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