Oleuropein and Verbascoside - Their Inhibition Effects on Carbonic Anhydrase and Molecular Docking Studies

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dc.authoridTaslimi, Parham/0000-0002-3171-0633
dc.authoridGulcin, ilhami/0000-0001-5993-1668
dc.authoridAGGUL, AHMET GOKHAN/0000-0003-0377-0388
dc.contributor.authorAggul, Ahmet Gokhan
dc.contributor.authorTaslimi, Parham
dc.contributor.authorKuzu, Muslum
dc.contributor.authorUzun, Naim
dc.contributor.authorBilginer, Sinan
dc.contributor.authorGulcin, Ilhami
dc.date.accessioned2024-09-29T16:09:57Z
dc.date.available2024-09-29T16:09:57Z
dc.date.issued2021
dc.departmentKarabük Üniversitesien_US
dc.description.abstractRecently, carbonic anhydrase (CA, E.C.4.2.1.1) inhibitors from natural product have paved the way for novel drug design in the treatment and prevention of some global diseases such as glaucoma, diabetes, and cancer. For this purpose, the inhibition effects of oleuropein and verbascoside from olive (Olea europaea L.) oil on human carbonic anhydrase I, and II (hCA I, and II) isoenzymes were evaluated in the current study. The inhibition effects of both natural compounds were determined by the esterase activity (in vitro). IC50 value of oleuropein and verbascoside was calculated as 1.57 and 1.73 mu M for hCA I isoenzyme, respectively. At the same manner, K-i values were determined as 1.25 +/- 0.42 and 2.00 +/- 0.42 mu M, respectively. Then, IC50 value of each compound for hCA II isoenzyme was calculated as 2.23 and 1.90 mu M, respectively. Similarly, K-i values were determined as 2.37 +/- 0.87 mu M and 1.49 +/- 0.33 mu M, respectively. Also, the inhibitory effects and potent binding mechanisms of oleuropein and verbascoside on hCA I, and II isoenzymes were realized by molecular docking studies. Consequently, both natural phenolic compounds demonstrated the potent inhibition profiles against the both isoenzymes. Therefore, we believe that these results may break new ground in the drug development for the treatment of some global disorders.en_US
dc.identifier.doi10.5650/jos.ess21106
dc.identifier.endpage1283en_US
dc.identifier.issn1345-8957
dc.identifier.issn1347-3352
dc.identifier.issue9en_US
dc.identifier.pmid34483220en_US
dc.identifier.scopus2-s2.0-85114624383en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1275en_US
dc.identifier.urihttps://doi.org/10.5650/jos.ess21106
dc.identifier.urihttps://hdl.handle.net/20.500.14619/7865
dc.identifier.volume70en_US
dc.identifier.wosWOS:000709764400010en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherJapan Oil Chemists Socen_US
dc.relation.ispartofJournal of Oleo Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectoleuropeinen_US
dc.subjectverbascosideen_US
dc.subjectcarbonic anhydraseen_US
dc.subjectenzyme inhibitionen_US
dc.subjectmolecular dockingen_US
dc.titleOleuropein and Verbascoside - Their Inhibition Effects on Carbonic Anhydrase and Molecular Docking Studiesen_US
dc.typeArticleen_US

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