Exercise Prevents Glucocorticoid-Induced Myocardial 4-Hydroxynonenal Production

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dc.authoridhayta, umit/0000-0001-5826-6555
dc.authoridGURAY, UMIT/0000-0002-6604-2970
dc.authoridGUNGOR, IREM/0000-0002-5037-0988
dc.authoridAkin, Senay/0000-0001-5729-5944
dc.authoridDemirel, Haydar/0000-0003-3334-4793
dc.contributor.authorHayta, Umit
dc.contributor.authorAkin, Senay
dc.contributor.authorGungor, Irem
dc.contributor.authorColluoglu, Inci Tugce
dc.contributor.authorGuray, Umit
dc.contributor.authorAkin, Yesim
dc.contributor.authorDemirel, Haydar A.
dc.date.accessioned2024-09-29T15:51:13Z
dc.date.available2024-09-29T15:51:13Z
dc.date.issued2023
dc.departmentKarabük Üniversitesien_US
dc.description.abstractPurpose Long-term administration of glucocorticoids (GCs) increases myocardial oxidative stress. 4-Hydroxynonenal (4-HNE) protein adducts, a marker of oxidative damage, have been associated with several cardiovascular diseases, including atherosclerosis, cardiac hypertrophy, cardiomyopathy, and ischemia-reperfusion injury. Exercise training has been shown to have a protective effect on the heart by lowering the level of oxidative stress in cardiomyocytes. Therefore, we aimed to investigate the effect of long-term dexamethasone treatment and exercise training on myocardial 4-HNE levels.Methods Twenty-four female Wistar albino rats were assigned to sedentary control-saline treated (C, n = 8), sedentary-dexamethasone treated (D, n = 8), and exercise training-dexamethasone treated (DE, n = 8) groups. Daily dexamethasone was injected for 28 days at a 1 mg kg(-1) dose, while C animals were injected with the same volume of saline subcutaneously. DE animals underwent an exercise training protocol of 60 min/day, 5 days a week, at 25 m/min(-1) (0% grade) for 28 days. Left ventricular 4-HNE, Hsp72 levels, and pHsp25/Hsp25 ratio were determined by Western blot.Results The administration of dexamethasone led to a significant elevation in 4-HNE levels in the myocardium of adult rats (p < 0.05; D vs. C). The concurrent implementation of exercise training impeded this increase (p > 0.05; DE vs. C). Exercise training induced a threefold increase in myocardial Hsp72 expression (p < 0.001; DE vs. C and D) and attenuated the dexamethasone-induced increase in Hsp25 phosphorylation (p < 0.05; C vs. D) (p < 0.001; DE vs. D).Conclusion Our results indicate that long-term administration of dexamethasone is associated with an increase in cardiac 4-HNE levels, which is hindered by the addition of exercise training.en_US
dc.identifier.doi10.1007/s10557-023-07506-4
dc.identifier.issn0920-3206
dc.identifier.issn1573-7241
dc.identifier.pmid37624527en_US
dc.identifier.scopus2-s2.0-85168966413en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1007/s10557-023-07506-4
dc.identifier.urihttps://hdl.handle.net/20.500.14619/3930
dc.identifier.wosWOS:001063581700001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofCardiovascular Drugs and Therapyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDexamethasoneen_US
dc.subjectOxidative stressen_US
dc.subjectExercise trainingen_US
dc.subjectCardiomyocyteen_US
dc.subjectHsp72en_US
dc.subjectHsp25en_US
dc.titleExercise Prevents Glucocorticoid-Induced Myocardial 4-Hydroxynonenal Productionen_US
dc.typeArticleen_US

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