Nanocrystalline Zn2+ and SO42- binary doped fluorohydroxyapatite: A novel biomaterial with enhanced osteoconductive and osteoinconductive properties

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dc.authoridTezcaner, Aysen/0000-0003-4292-5856
dc.authoridEvis, Zafer/0000-0002-7518-8162
dc.authoridDalgic, Ali Deniz/0000-0003-2904-1204
dc.authoridPazarceviren, Ahmet Engin/0000-0001-5233-860X
dc.authoridAlshemary, Ammar Z/0000-0001-5367-1869
dc.contributor.authorAlshemary, Ammar Z.
dc.contributor.authorPazarceviren, Engin Ahmet
dc.contributor.authorDalgic, Ali Deniz
dc.contributor.authorTezcaner, Amen
dc.contributor.authorKeskin, Dilek
dc.contributor.authorEvis, Zafer
dc.date.accessioned2024-09-29T16:00:27Z
dc.date.available2024-09-29T16:00:27Z
dc.date.issued2019
dc.departmentKarabük Üniversitesien_US
dc.description.abstractIn this study, we have successfully doped hydroxyapatite (HA) with zinc (Zn2+), sulphate (SO42-) and fluoride (F-) ions to develop a new composition of bioceramic, Ca10-xZnx(PO4)(6-y)(SO4)(y)(OH)(2-z-y)F-z(SO4)(y), (x = 0, 0.2, 0.6, 1.0, y = 0, 0.5 and z = 0,1.0 mol), using wet precipitation method. The obtained materials were analysed using XRD, FTIR, FESEM, and XPS techniques to investigate the phase purity, particle morphology and elemental composition, respectively. A model anticancer drug (Doxorubicin, DOX) was loaded onto the surface of the Zn/SO4-FHA materials. About 100% loading of DOX with a controlled release profile was obtained. Degradation of materials in Simulated body fluid (SBF) was greatly improved with the incorporation of Zn2+/SO42- ions in comparison to HA/FHA, which makes it highly bioactive materials. In vitro cell viability and adhesion of Human fetal osteoblast (hFOB) cell were investigated. Cell viability has demonstrated that the hFOB cells proliferated at a high rate on Zn/SO4-FHA materials, confirming the in vitro biocompatibility of the materials. Alkaline phosphatase (ALP) activity and intracellular calcium deposition of hFOB cells seeded on 1ZnSO(4)-FHA disc surface was statistically higher than observed on pure HA and FHA discs, indicating that hFOB cells differentiated into mature osteoblasts on 1Zn/SO4-FHA disc surfaces. Taken together, our results suggest that HA substituted by (Zn2+, 0.2 mol), (SO42-, 0.5 mol) and (F-, 1 mol) (1Zn/So(4)-FHA) material was a promising material for hard tissue scaffolds.en_US
dc.description.sponsorshipKarabuk University [KBUBAP-17-KP-477]en_US
dc.description.sponsorshipDr. Ammar Z. Alshemary would like to thank Karabuk University for providing financial support via Project no. KBUBAP-17-KP-477.en_US
dc.identifier.doi10.1016/j.msec.2019.109884
dc.identifier.issn0928-4931
dc.identifier.issn1873-0191
dc.identifier.pmid31500005en_US
dc.identifier.scopus2-s2.0-85067265129en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1016/j.msec.2019.109884
dc.identifier.urihttps://hdl.handle.net/20.500.14619/5159
dc.identifier.volume104en_US
dc.identifier.wosWOS:000487569300022en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofMaterials Science and Engineering C-Materials For Biological Applicationsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSubstituted hydroxyapatiteen_US
dc.subjectStructural characterizationen_US
dc.subjectDrug deliveryen_US
dc.subjectIn vitro bioactivityen_US
dc.subjectCell proliferationen_US
dc.subjectOsteogenic differentiationen_US
dc.titleNanocrystalline Zn2+ and SO42- binary doped fluorohydroxyapatite: A novel biomaterial with enhanced osteoconductive and osteoinconductive propertiesen_US
dc.typeArticleen_US

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