Trends in heart failure between 2016 and 2022 in Türkiye (TRends-HF): a nationwide retrospective cohort study of 85 million individuals across entire population of all ages

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dc.authoridCelik, Ahmet/0000-0002-9417-7610
dc.authoridYILMAZ, MEHMET BIRHAN/0000-0002-8169-8628
dc.authoridSahin, Anil/0000-0003-3416-5965
dc.contributor.authorCelik, Ahmet
dc.contributor.authorUral, Dilek
dc.contributor.authorSahin, Anil
dc.contributor.authorColluoglu, Inci Tugce
dc.contributor.authorKanik, Emine Arzu
dc.contributor.authorAta, Naim
dc.contributor.authorArugaslan, Emre
dc.date.accessioned2024-09-29T15:57:51Z
dc.date.available2024-09-29T15:57:51Z
dc.date.issued2023
dc.departmentKarabük Üniversitesien_US
dc.description.abstractBackground Data on the burden of heart failure (HF) outside western countries are limited, but available data suggest it may present differently in other countries. The aim of this study was to examine the incidence, prevalence, and survival rates of HF in Turkiye, with a specific focus on how these rates vary according to age, sex, comorbidities, and socioeconomic status (SES).Methods We harnessed the extensive National Electronic Database of the Turkish Ministry of Health, covering Turkey's entire population from January 1, 2016, to December 31, 2022, to identify 2,722,151 cases of HF and their associated comorbidities using ICD-10 codes. Analyzing the primary endpoint of all-cause mortality, our study utilized anonymized data to examine patient demographics, comorbidities, socioeconomic status, and survival patterns, employing statistical techniques to delve into relationships and trends. The data were segmented by gender, socioeconomic status, and age, involving cross-tabulations and statistical metrics to explore connections, odds ratios, and survival rates.Findings The estimated prevalence of HF was 2.114% in Turkiye at the end of 2022, with an annual incidence ranging between 3.00 and 6.06 per 1000 person years. Females were older than males (69.8 +/- 13.9 years vs. 66.8 +/- 13.9 years, respectively). The most common comorbidities were congenital heart diseases and anemia under the age of 20, and hypertension and atherosclerotic cardiovascular disease in the adult population. Only 23.6% (643,159/2,722,151) of patients were treated with any triple guideline-directed medical therapy (GDMT) and 3.6% (96,751/2,722,151) of patients were on quadruple GDMT. The survival rates for patients with HF at 1, 5, and 7 years were 83.3% (95% CI: 83.2-83.3), 61.5% (95% CI: 61.4-61.6), and 57.7% (95% CI: 57.6-57.8) among females, and 82.1% (95% CI: 82.0-82.2), 58.2% (95% CI: 58.1-58.3), and 54.2% (95% CI: 54.0-54.3) among males. Despite a tendency for an increase from the highest to the lowest SES, the prevalence of HF and mortality were paradoxically lowest in the lowest SES region.Interpretation The prevalence, incidence, and survival rates of HF in Turkiye were comparable to western countries, despite the notable difference of HF onset occurring 8-10 years earlier in the Turkish population. Drug usage statistics indicate there is a need for effective strategies to improve treatment with GDMT.en_US
dc.identifier.doi10.1016/j.lanepe.2023.100723
dc.identifier.issn2666-7762
dc.identifier.pmid37953995en_US
dc.identifier.scopus2-s2.0-85172238886en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1016/j.lanepe.2023.100723
dc.identifier.urihttps://hdl.handle.net/20.500.14619/5026
dc.identifier.volume33en_US
dc.identifier.wosWOS:001089896900001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofLancet Regional Health-Europeen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHeart failureen_US
dc.subjectPrevalenceen_US
dc.subjectSocioeconomic statusen_US
dc.subjectElectronic health recordsen_US
dc.titleTrends in heart failure between 2016 and 2022 in Türkiye (TRends-HF): a nationwide retrospective cohort study of 85 million individuals across entire population of all agesen_US
dc.typeArticleen_US

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