Variation in SWI/SNF Chromatin Remodeling Complex Proteins is Associated with Alcohol Dependence and Antisocial Behavior in Human Populations

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dc.authorid/0000-0003-2291-6880
dc.authoridPandey, Ashwini Kumar/0000-0002-2688-7901
dc.authoridKuperman, Samuel/0000-0002-5995-1981
dc.authoridDick, Danielle/0000-0002-1636-893X
dc.authoridAnokhin, Andrey/0000-0001-8158-6346
dc.authoridTischfield, Jay/0000-0003-3217-8287
dc.contributor.authorMathies, Laura D.
dc.contributor.authorAliev, Fazil
dc.contributor.authorDavies, Andrew G.
dc.contributor.authorDick, Danielle M.
dc.contributor.authorBettinger, Jill C.
dc.date.accessioned2024-09-29T16:04:32Z
dc.date.available2024-09-29T16:04:32Z
dc.date.issued2017
dc.departmentKarabük Üniversitesien_US
dc.description.abstractBackgroundTesting for direct gene or single nucleotide polymorphism replication of association across studies may not capture the true importance of a candidate locus; rather, we suggest that relevant replication across studies may be found at the level of a biological process. We previously observed that variation in 2 members of the switching defective/sucrose nonfermenting (SWI/SNF) chromatin remodeling complex is associated with alcohol dependence (AD) in the Irish Affected Sib Pair Study for Alcohol Dependence. Here, we tested for association with alcohol-related outcomes using a set of genes functioning in the SWI/SNF complex in 2 independent samples. MethodsWe used a set-based analysis to examine the 29 genes of the SWI/SNF complex for evidence of association with (i) AD in the adult Collaborative Study on the Genetics of Alcoholism (COGA) case-control sample and (ii) antisocial behavior, hypothesized to be a genetically related developmental precursor, in a younger population sample (Spit for Science [S4S]). ResultsWe found evidence for association of the SWI/SNF complex with AD in COGA (p=0.0435) and more general antisocial behavior in S4S (p=0.00026). The genes that contributed most strongly to the signal in COGA were SS18L1, SMARCD1, BRD7, BCL7B, SMARCB1, and BCL11A. In the S4S sample, ACTB, ARID2, BCL11A, BCL11B, BCL7B, BCL7C, DPF2, and DPF3 all contributed strongly to the signal. ConclusionsWe detected associations between the SWI/SNF complex and AD in an adult population selected from treatment-seeking probands and antisocial behavior in an adolescent population sample. This provides strong support for a role for SWI/SNF in the development of alcohol-related problems.en_US
dc.description.sponsorshipNIH from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) [U10AA008401]; National Institute on Drug Abuse (NIDA); Virginia Commonwealth University; National Institute on Alcohol Abuse and Alcoholism [P20 AA017828, R37AA011408, K02AA018755, P50 AA022537]; National Center for Research Resources and National Institutes of Health Roadmap for Medical Research [UL1RR031990]; NIH [R01AA024482, P50AA022537]en_US
dc.description.sponsorshipWe continue to be inspired by our memories of Henri Begleiter and Theodore Reich, founding PI and Co-PI of COGA, and also owe a debt of gratitude to other past organizers of COGA, including Ting-Kai Li, P. Michael Conneally, Raymond Crowe, and Wendy Reich, for their critical contributions. This national collaborative study is supported by NIH grant U10AA008401 from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) and the National Institute on Drug Abuse (NIDA). The authors declare that they have no conflicts of interest.; We would like to thank the VCU students for making this study a success, as well as the many VCU faculty, students, and staff who contributed to the design and implementation of the project. Spit for Science: The VCU Student Survey has been supported by Virginia Commonwealth University, P20 AA017828, R37AA011408, K02AA018755 (to DMD), and P50 AA022537 from the National Institute on Alcohol Abuse and Alcoholism, and UL1RR031990 from the National Center for Research Resources and National Institutes of Health Roadmap for Medical Research. These funding sources had no role in the analysis or interpretation of the data, writing of the manuscript, or the decision to submit the study for publication. JCB, LDM, and AGD are supported by NIH R01AA024482 and P50AA022537.en_US
dc.identifier.doi10.1111/acer.13514
dc.identifier.endpage2040en_US
dc.identifier.issn0145-6008
dc.identifier.issn1530-0277
dc.identifier.issue12en_US
dc.identifier.pmid28981154en_US
dc.identifier.scopus2-s2.0-85032587029en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage2033en_US
dc.identifier.urihttps://doi.org/10.1111/acer.13514
dc.identifier.urihttps://hdl.handle.net/20.500.14619/6194
dc.identifier.volume41en_US
dc.identifier.wosWOS:000416832600006en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofAlcoholism-Clinical and Experimental Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAlcohol Dependenceen_US
dc.subjectSwitching Defectiveen_US
dc.subjectSucrose Nonfermentingen_US
dc.subjectCollaborative Study on the Genetics of Alcoholismen_US
dc.subjectChromatin Remodelingen_US
dc.subjectExternalizingen_US
dc.subjectAntisocial Behavioren_US
dc.titleVariation in SWI/SNF Chromatin Remodeling Complex Proteins is Associated with Alcohol Dependence and Antisocial Behavior in Human Populationsen_US
dc.typeArticleen_US

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